Abstract
In a randomized Eastern Cooperative Oncology Group study, single-agent ifosfamide used to treat extensive-disease small cell lung cancer patients produced a 49% response rate compared with 56% for patients receiving standard combination chemotherapy (cyclophosphamide/doxorubicin/vincristine). When the drug was combined with carboplatin and etoposide to treat extensive- disease small cell lung cancer patients, overall response rate was 83%, median survival time was 9 months, and 2-year survival rate was 14%. The major toxicity wets myelosuppression. These results confirm those of other investigators who have shown the effectiveness of the ifosfamide/carboplatin/etoposide regimen in treating patients with small cell lung cancer.
Original language | English (US) |
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Pages (from-to) | 23-27 |
Number of pages | 5 |
Journal | Seminars in oncology |
Volume | 22 |
Issue number | 1 SUPPL. 2 |
State | Published - 1995 |
ASJC Scopus subject areas
- Hematology
- Oncology