The PIK3CA gene is mutated with high frequency in human breast cancers

Kurtis E. Bachman, Pedram Argani, Yardena Samuels, Natalie Silliman, Janine Ptak, Steve Szabo, Hiroyuki Konishi, Bedri Karakas, Brian G. Blair, Clarence Lin, Brock A. Peters, Victor E. Velculescu, Ben Ho Park

Research output: Contribution to journalArticlepeer-review

529 Scopus citations


The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been reported that somatic mutations within the PI3K subunit p110α (PIK3CA) are present in human colorectal and other cancers. Here we show that thirteen of fifty-three breast cancers (25%) contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain. These results demonstrate that PIK3CA is the most mutated oncogene in breast cancer and support a role for PIK3CA in epithelial carcinogenesis.

Original languageEnglish (US)
Pages (from-to)772-775
Number of pages4
JournalCancer Biology and Therapy
Issue number8
StatePublished - Aug 2004


  • Breast cancer
  • Mutation
  • Oncogene
  • PI3 kinase
  • PIK3CA

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research


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