The physics of cancer: The role of physical interactions and mechanical forces in metastasis

Denis Wirtz, K Konstantopoulos, Peter C. Searson

Research output: Contribution to journalArticle

Abstract

Metastasis is a complex, multistep process responsible for >90% of cancer-related deaths. In addition to genetic and external environmental factors, the physical interactions of cancer cells with their microenvironment, as well as their modulation by mechanical forces, are key determinants of the metastatic process. We reconstruct the metastatic process and describe the importance of key physical and mechanical processes at each step of the cascade. The emerging insight into these physical interactions may help to solve some long-standing questions in disease progression and may lead to new approaches to developing cancer diagnostics and therapies.

Original languageEnglish (US)
Pages (from-to)512-522
Number of pages11
JournalNature Reviews Cancer
Volume11
Issue number7
DOIs
StatePublished - Jul 2011

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Physics
Neoplasm Metastasis
Mechanical Phenomena
Physical Phenomena
Neoplasms
Cell Communication
Disease Progression
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The physics of cancer : The role of physical interactions and mechanical forces in metastasis. / Wirtz, Denis; Konstantopoulos, K; Searson, Peter C.

In: Nature Reviews Cancer, Vol. 11, No. 7, 07.2011, p. 512-522.

Research output: Contribution to journalArticle

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