The Phosphoinositide-3 kinase survival signaling mechanism in sepsis

Mariuxi C. Manukyan; Brent R. Weil; Yue Wang; Aaron M. Abarbanell; Jeremy L. Herrmann; Jeffrey A. Poynter; Daniel R. Meldrum

doi:10.1097/SHK.0b013e3181e14ea9

The Phosphoinositide-3 kinase survival signaling mechanism in sepsis

Mariuxi C. Manukyan, Brent R. Weil, Yue Wang, Aaron M. Abarbanell, Jeremy L. Herrmann, Jeffrey A. Poynter, Daniel R. Meldrum

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.

Original language	English (US)
Pages (from-to)	442-449
Number of pages	8
Journal	Shock
Volume	34
Issue number	5
DOIs	https://doi.org/10.1097/SHK.0b013e3181e14ea9
State	Published - Nov 2010
Externally published	Yes

Keywords

PI3K
host defense
immune response
inflammation
septic shock

ASJC Scopus subject areas

Emergency Medicine
Critical Care and Intensive Care Medicine

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10.1097/SHK.0b013e3181e14ea9

Cite this

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title = "The Phosphoinositide-3 kinase survival signaling mechanism in sepsis",

abstract = "Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.",

keywords = "PI3K, host defense, immune response, inflammation, septic shock",

author = "Manukyan, {Mariuxi C.} and Weil, {Brent R.} and Yue Wang and Abarbanell, {Aaron M.} and Herrmann, {Jeremy L.} and Poynter, {Jeffrey A.} and Meldrum, {Daniel R.}",

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AU - Manukyan, Mariuxi C.

AU - Weil, Brent R.

AU - Wang, Yue

AU - Abarbanell, Aaron M.

AU - Herrmann, Jeremy L.

AU - Poynter, Jeffrey A.

AU - Meldrum, Daniel R.

PY - 2010/11

Y1 - 2010/11

N2 - Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.

AB - Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.

KW - PI3K

KW - host defense

KW - immune response

KW - inflammation

KW - septic shock

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The Phosphoinositide-3 kinase survival signaling mechanism in sepsis

Abstract

Keywords

ASJC Scopus subject areas

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