The phosphocreatine overshoot occurs independent of myocardial work

L. J. Kaplan; C. F. Bellows; S. Carter; H. Blum; G. J.R. Whitman

doi:10.1016/0300-9084(96)88131-4

The phosphocreatine overshoot occurs independent of myocardial work

L. J. Kaplan, C. F. Bellows, S. Carter, H. Blum, G. J.R. Whitman

Research output: Contribution to journal › Article › peer-review

Abstract

Although the exact mechanism(s) responsible for the phosphocreatine/ATP overshoot have not been completely elucidated, our data demonstrate that the overshoot does not stem from reduced myocardial work, and consequently, reduced utilization of phosphocreatine (PCr). Additionally, we highlight a basic difference in the physiologic responses of skeletal and cardial muscle to work demands. By understanding the bioenergetic derangements which accompany reperfusion injury, one may hope to better salvage post-ischemic myocardium.

Original language	English (US)
Pages (from-to)	245-248
Number of pages	4
Journal	Biochimie
Volume	77
Issue number	4
DOIs	https://doi.org/10.1016/0300-9084(96)88131-4
State	Published - 1995
Externally published	Yes

Keywords

myocardial work
phosphocreatine overshoot
post-ischemic myocardium

ASJC Scopus subject areas

Biochemistry

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keywords = "myocardial work, phosphocreatine overshoot, post-ischemic myocardium",

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AU - Bellows, C. F.

AU - Carter, S.

AU - Blum, H.

AU - Whitman, G. J.R.

PY - 1995

Y1 - 1995

N2 - Although the exact mechanism(s) responsible for the phosphocreatine/ATP overshoot have not been completely elucidated, our data demonstrate that the overshoot does not stem from reduced myocardial work, and consequently, reduced utilization of phosphocreatine (PCr). Additionally, we highlight a basic difference in the physiologic responses of skeletal and cardial muscle to work demands. By understanding the bioenergetic derangements which accompany reperfusion injury, one may hope to better salvage post-ischemic myocardium.

AB - Although the exact mechanism(s) responsible for the phosphocreatine/ATP overshoot have not been completely elucidated, our data demonstrate that the overshoot does not stem from reduced myocardial work, and consequently, reduced utilization of phosphocreatine (PCr). Additionally, we highlight a basic difference in the physiologic responses of skeletal and cardial muscle to work demands. By understanding the bioenergetic derangements which accompany reperfusion injury, one may hope to better salvage post-ischemic myocardium.

KW - myocardial work

KW - phosphocreatine overshoot

KW - post-ischemic myocardium

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ER -

The phosphocreatine overshoot occurs independent of myocardial work

Abstract

Keywords

ASJC Scopus subject areas

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