The pharmacokinetic plasma profile of mitomycin C, measured after sequential intermittent intravenous administration

J. Lankelma; M. Stuurman; J. Van Hoogenhuijze; A. Van Bochove; J. B. Vermorken; J. Verweij; H. M. Pinedo

doi:10.1016/0277-5379(88)90249-0

The pharmacokinetic plasma profile of mitomycin C, measured after sequential intermittent intravenous administration

J. Lankelma, M. Stuurman, J. Van Hoogenhuijze, A. Van Bochove, J. B. Vermorken, J. Verweij, H. M. Pinedo

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Abstract

The pharmacokinetic plasma profile of mitomycin C (MMC) was studied during sequential courses in man. MMC was given repeatedly as i.v. bolus injections at fixed dose levels to the same patient either as a single agent or as part of different combination chemotherapy regimens. Large interindividual variations between the various pharmacokinetic parameters were observed. Statistical analysis showed no significant differences between average pharmacokinetic parameters when comparing the first and the second MMC injection, except for the total body clearance (Cl_tot). The Cl_tot was higher for the second injection when compared to the first injection in a group of patients who received MMC as a single agent (10 patients). For a group of patients receiving MMC as part of a combination therapy the average values of Cl_tot of the first when compared to the second injection were not statistically different (nine patients). This observation could not be correlated with clinical observations on toxicities.

Original language	English (US)
Pages (from-to)	175-180
Number of pages	6
Journal	European Journal of Cancer and Clinical Oncology
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0277-5379(88)90249-0
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Oncology

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10.1016/0277-5379(88)90249-0

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title = "The pharmacokinetic plasma profile of mitomycin C, measured after sequential intermittent intravenous administration",

abstract = "The pharmacokinetic plasma profile of mitomycin C (MMC) was studied during sequential courses in man. MMC was given repeatedly as i.v. bolus injections at fixed dose levels to the same patient either as a single agent or as part of different combination chemotherapy regimens. Large interindividual variations between the various pharmacokinetic parameters were observed. Statistical analysis showed no significant differences between average pharmacokinetic parameters when comparing the first and the second MMC injection, except for the total body clearance (Cltot). The Cltot was higher for the second injection when compared to the first injection in a group of patients who received MMC as a single agent (10 patients). For a group of patients receiving MMC as part of a combination therapy the average values of Cltot of the first when compared to the second injection were not statistically different (nine patients). This observation could not be correlated with clinical observations on toxicities.",

author = "J. Lankelma and M. Stuurman and {Van Hoogenhuijze}, J. and {Van Bochove}, A. and Vermorken, {J. B.} and J. Verweij and Pinedo, {H. M.}",

year = "1988",

doi = "10.1016/0277-5379(88)90249-0",

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T1 - The pharmacokinetic plasma profile of mitomycin C, measured after sequential intermittent intravenous administration

AU - Lankelma, J.

AU - Stuurman, M.

AU - Van Hoogenhuijze, J.

AU - Van Bochove, A.

AU - Vermorken, J. B.

AU - Verweij, J.

AU - Pinedo, H. M.

PY - 1988

Y1 - 1988

N2 - The pharmacokinetic plasma profile of mitomycin C (MMC) was studied during sequential courses in man. MMC was given repeatedly as i.v. bolus injections at fixed dose levels to the same patient either as a single agent or as part of different combination chemotherapy regimens. Large interindividual variations between the various pharmacokinetic parameters were observed. Statistical analysis showed no significant differences between average pharmacokinetic parameters when comparing the first and the second MMC injection, except for the total body clearance (Cltot). The Cltot was higher for the second injection when compared to the first injection in a group of patients who received MMC as a single agent (10 patients). For a group of patients receiving MMC as part of a combination therapy the average values of Cltot of the first when compared to the second injection were not statistically different (nine patients). This observation could not be correlated with clinical observations on toxicities.

AB - The pharmacokinetic plasma profile of mitomycin C (MMC) was studied during sequential courses in man. MMC was given repeatedly as i.v. bolus injections at fixed dose levels to the same patient either as a single agent or as part of different combination chemotherapy regimens. Large interindividual variations between the various pharmacokinetic parameters were observed. Statistical analysis showed no significant differences between average pharmacokinetic parameters when comparing the first and the second MMC injection, except for the total body clearance (Cltot). The Cltot was higher for the second injection when compared to the first injection in a group of patients who received MMC as a single agent (10 patients). For a group of patients receiving MMC as part of a combination therapy the average values of Cltot of the first when compared to the second injection were not statistically different (nine patients). This observation could not be correlated with clinical observations on toxicities.

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JO - European Journal of Cancer and Clinical Oncology

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IS - 2

ER -

The pharmacokinetic plasma profile of mitomycin C, measured after sequential intermittent intravenous administration

Abstract

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