The peritrophic matrix limits the rate of digestion in adult Anopheles stephensi and Aedes aegypti mosquitoes

J. M. Villalon, A. Ghosh, M. Jacobs-Lorena

Research output: Contribution to journalArticlepeer-review

Abstract

The peritrophic matrix (PM) is a chitin-containing acellular sheath that surrounds the blood meal and separates the food bolus from the midgut epithelium. Intense molecular traffic through the PM occurs during digestion. Digestive enzymes secreted by the midgut epithelium must traverse the PM to reach their substrates in the food bolus, and digestion products must cross the PM in the opposite direction to be absorbed by the epithelial cells. Here we report that the PM limits the rate of digestion. PM disruption by two independent means (chitinase and anti-PM antibodies) consistently increases the rate of blood digestion. The significance of these results in relation to PM function is discussed.

Original languageEnglish (US)
Pages (from-to)891-895
Number of pages5
JournalJournal of Insect Physiology
Volume49
Issue number10
DOIs
StatePublished - Oct 1 2003

Keywords

  • Digestion
  • Mosquito
  • Peritrophic matrix

ASJC Scopus subject areas

  • Physiology
  • Insect Science

Fingerprint

Dive into the research topics of 'The peritrophic matrix limits the rate of digestion in adult Anopheles stephensi and Aedes aegypti mosquitoes'. Together they form a unique fingerprint.

Cite this