This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.
|Original language||English (US)|
|Number of pages||6|
|State||Published - 1997|
- False postive rate
- Multipoint identity-by-descent method (MIM)
- Peak length
ASJC Scopus subject areas