The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs

Yin Y. Shugart; David E. Goldgar

doi:10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H

The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs

Yin Y. Shugart, David E. Goldgar

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.

Original language	English (US)
Pages (from-to)	897-902
Number of pages	6
Journal	Genetic Epidemiology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H
State	Published - 1997
Externally published	Yes

Keywords

False postive rate
MAPMAKER/SIBS
Multipoint identity-by-descent method (MIM)
Peak length
Power

ASJC Scopus subject areas

Genetics(clinical)
Epidemiology

Access to Document

10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H

Cite this

@article{18e5686de6494034806fb6cf4faea3f2,

title = "The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs",

abstract = "This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.",

keywords = "False postive rate, MAPMAKER/SIBS, Multipoint identity-by-descent method (MIM), Peak length, Power",

author = "Shugart, {Yin Y.} and Goldgar, {David E.}",

year = "1997",

doi = "10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H",

language = "English (US)",

volume = "14",

pages = "897--902",

journal = "Genetic Epidemiology",

issn = "0741-0395",

publisher = "Wiley-Liss Inc.",

number = "6",

}

TY - JOUR

T1 - The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs

AU - Shugart, Yin Y.

AU - Goldgar, David E.

PY - 1997

Y1 - 1997

N2 - This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.

AB - This paper summarizes the results of searching for evidence of loci contributing to simulated quantitative traits which are associated with a common genetic disease using two multipoint identity by descent (IBD) sharing methods: MIM and MAPMAKER/SIBS. In brief, by varying the lod-score threshold from 1 to 3, we found that MIM and MAPMAKER/SIBS have similar power to detect linkage, but MAPMAKER/SIBS consistently produces a higher number of false positives.

KW - False postive rate

KW - MAPMAKER/SIBS

KW - Multipoint identity-by-descent method (MIM)

KW - Peak length

KW - Power

UR - http://www.scopus.com/inward/record.url?scp=0031442619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031442619&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H

DO - 10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H

M3 - Article

C2 - 9433597

AN - SCOPUS:0031442619

SN - 0741-0395

VL - 14

SP - 897

EP - 902

JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 6

ER -

The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this