The peptide molecular links between the central nervous and the immune systems

I. Z. Siemion, A. Kluczyk, M. Cebrat

Research output: Contribution to journalArticlepeer-review

Abstract

The central nervous system (CNS) and the immune system were for many years considered as two autonomous systems. Now, the reciprocal connections between them are generally recognized and very well documented. The links are realized mainly by various immuno- and neuropeptides. In the review the influence of the following immunopeptides on CNS is presented: tuftsin, thymulin, thymopoietin and thymopentin, thymosins, and thymic humoral factor. On the other side, the activity in the immune system of such neuropeptides as substance P, neurotensin, some neurokinins, enkephalins, and endorphins is discussed.

Original languageEnglish (US)
Pages (from-to)161-176
Number of pages16
JournalAmino Acids
Volume29
Issue number3
DOIs
StatePublished - Nov 2005
Externally publishedYes

Keywords

  • CNS-immune system molecular links
  • Immunopeptides
  • Neuropeptides
  • Thymic peptides

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

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