The pedunculopontine nucleus in Parkinson's disease

R. M. Zweig, W. R. Jankel, J. C. Hedreen, R. Mayeux, D. L. Price

Research output: Contribution to journalArticle

Abstract

This study demonstrated a significant loss of neurons within the lateral part of the pedunculopontine nucleus pars compacta in individuals with idiopathic Parkinson's disease and in individuals with combined Parkinson's and Alzheimer's disease. We also examined the extent of neuronal loss within the substantia nigra pars compacta, locus ceruleus, dorsal raphe nucleus, and nucleus basalis of Meynert. The number of pedunculopontine nucleus pars compacta neurons in the patients with Parkinson's or Parkinson's and Alzheimer's disease was reduced (average, 40%) in comparison with the number in control subjects or patients with Alzheimer's disease (p <0.01). This finding correlated significantly with the extent of loss of substantia nigra pars compacta neurons (p <0.01).

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalAnnals of Neurology
Volume26
Issue number1
StatePublished - 1989

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Parkinson Disease
Alzheimer Disease
Neurons
Basal Nucleus of Meynert
Locus Coeruleus
Pars Compacta

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zweig, R. M., Jankel, W. R., Hedreen, J. C., Mayeux, R., & Price, D. L. (1989). The pedunculopontine nucleus in Parkinson's disease. Annals of Neurology, 26(1), 41-46.

The pedunculopontine nucleus in Parkinson's disease. / Zweig, R. M.; Jankel, W. R.; Hedreen, J. C.; Mayeux, R.; Price, D. L.

In: Annals of Neurology, Vol. 26, No. 1, 1989, p. 41-46.

Research output: Contribution to journalArticle

Zweig, RM, Jankel, WR, Hedreen, JC, Mayeux, R & Price, DL 1989, 'The pedunculopontine nucleus in Parkinson's disease', Annals of Neurology, vol. 26, no. 1, pp. 41-46.
Zweig RM, Jankel WR, Hedreen JC, Mayeux R, Price DL. The pedunculopontine nucleus in Parkinson's disease. Annals of Neurology. 1989;26(1):41-46.
Zweig, R. M. ; Jankel, W. R. ; Hedreen, J. C. ; Mayeux, R. ; Price, D. L. / The pedunculopontine nucleus in Parkinson's disease. In: Annals of Neurology. 1989 ; Vol. 26, No. 1. pp. 41-46.
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