The pathways of oxygen in brain II: Competitions for cytochrome c oxidase and NOS are keys to flow-metabolism coupling

Albert Gjedde

Research output: Contribution to journalArticlepeer-review

Abstract

It has been well-known for many years that cerebral oxygen consumption remains constant during moderate changes of blood flow, as measured during hypo- or hypercapnia or indomethacin administration. Current models of flow-metabolism coupling link blood-brain transfer of oxygen to oxygen metabolism in mitochondria. The resulting quantitative relations between flow and metabolism reveal that a close link between diffusion and metabolism prevents the enzyme from maintaining a constant oxygen consumption when blood flow changes, unless the enzyme's affinity towards oxygen is adjusted commensurately.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalAdvances in experimental medicine and biology
Volume566
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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