The pathway for oxygen in brain

Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Blood-brain transfer of oxygen is a fundamental function of regional oxygen consumption. This function yielded a novel description of the mechanism of flow-metabolism coupling. The description revealed that constant oxygen consumption is not maintained by saturation of cytochrome oxidase but by adjustment of the enzyme's affinity towards oxygen. Interactions of oxygen and a factor that could be nitric oxide, at both cytochrome oxidase and nitric oxide synthase, match the affinities of both enzymes towards their respective substrates to the oxygen requirement of the tissue and, in doing so, explain several properties of flow-metabolism coupling.

Original languageEnglish (US)
Pages (from-to)146-153
Number of pages8
JournalAPMIS. Supplementum
Volume111
Issue number109
StatePublished - 2003
Externally publishedYes

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Oxygen
Brain
Electron Transport Complex IV
Oxygen Consumption
Enzymes
Nitric Oxide Synthase
Nitric Oxide

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology
  • Microbiology (medical)

Cite this

Gjedde, A. (2003). The pathway for oxygen in brain. APMIS. Supplementum, 111(109), 146-153.

The pathway for oxygen in brain. / Gjedde, Albert.

In: APMIS. Supplementum, Vol. 111, No. 109, 2003, p. 146-153.

Research output: Contribution to journalArticle

Gjedde, A 2003, 'The pathway for oxygen in brain', APMIS. Supplementum, vol. 111, no. 109, pp. 146-153.
Gjedde A. The pathway for oxygen in brain. APMIS. Supplementum. 2003;111(109):146-153.
Gjedde, Albert. / The pathway for oxygen in brain. In: APMIS. Supplementum. 2003 ; Vol. 111, No. 109. pp. 146-153.
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