The pathophysiology of renal allograft rejection: A collective review

Charles M. Balch, Arnold G. Diethelm

Research output: Contribution to journalArticlepeer-review


Renal allograft rejection represents the combined efforts of cellular and humoral immunity. The tissue targets are the renal allograft vasculature, and to a lesser extent, the glomeruli. The temporal sequence and predominant pathophysiological features of rejection are clearly related to histocompatibility differences between the donor organ and recipient. A better understanding of these pathophysiological processes has given some insight into its immunological sequelae of rejection. However, despite the rapidly expanding knowledge about renal allograft rejection, many basic tenets and a specific therapeutic approach remain to be eludicated.

Original languageEnglish (US)
Pages (from-to)350-380
Number of pages31
JournalJournal of Surgical Research
Issue number5
StatePublished - May 1972
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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