The pathophysiology of penicillamine-induced myasthenia gravis

R. W. Kuncl, A. Pestronk, Daniel B Drachman, E. Rechthand

Research output: Contribution to journalArticle

Abstract

The temporal course and pathophysiology of penicillamine-induced myasthenia gravis were studied in detail in a typical case. Our results suggest that this disorder and idiopathic autoimmune myasthenia gravis share the same essential pathophysiological features, including the presence of anti-acetylcholine receptor (AChR) antibody, serum-induced blockade of AChRs, antibody-mediated accelerated degradation of AChRs, and a resultant quantitative reduction in available junctional AChRs. An initial severe reduction in junctional AChRs was reversed and the patient recovered, both within 8 months of stopping penicillamine. Our data suggest that penicillamine probably produced myasthenia gravis by initiating a new autoimmune response rather than by enhancing ongoing autoimmunity.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
JournalAnnals of Neurology
Volume20
Issue number6
StatePublished - 1986

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Penicillamine
Myasthenia Gravis
Autoimmunity
Antibodies
Cholinergic Receptors
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kuncl, R. W., Pestronk, A., Drachman, D. B., & Rechthand, E. (1986). The pathophysiology of penicillamine-induced myasthenia gravis. Annals of Neurology, 20(6), 740-744.

The pathophysiology of penicillamine-induced myasthenia gravis. / Kuncl, R. W.; Pestronk, A.; Drachman, Daniel B; Rechthand, E.

In: Annals of Neurology, Vol. 20, No. 6, 1986, p. 740-744.

Research output: Contribution to journalArticle

Kuncl, RW, Pestronk, A, Drachman, DB & Rechthand, E 1986, 'The pathophysiology of penicillamine-induced myasthenia gravis', Annals of Neurology, vol. 20, no. 6, pp. 740-744.
Kuncl, R. W. ; Pestronk, A. ; Drachman, Daniel B ; Rechthand, E. / The pathophysiology of penicillamine-induced myasthenia gravis. In: Annals of Neurology. 1986 ; Vol. 20, No. 6. pp. 740-744.
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