The pathophysiology of intervertebral disc disease

Akwasi Ofori Boah; Nancy Abu-Bonsrah; C. Rory Goodwin; Daniel Sciubba

The pathophysiology of intervertebral disc disease

Akwasi Ofori Boah, Nancy Abu-Bonsrah, C. Rory Goodwin, Daniel Sciubba

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The degeneration of the intervertebral disc results from several multifactorial pathophysiologic processes. Here, we discuss the anatomy of the intervertebral disc along with a presentation of several pathologic processes including vascular insufficiency (possibly due to cigarette exposure and endothelial dysfunction), anatomic variations, poor nutritional status, infections, autoimmune and/or inflammatory processes, genetic predispositions and iatrogenic occurrences as well as exposure to drugs or toxins that lead to degeneration of the disc. This brief overview establishes a necessary starting point for the understanding of these processes as well as a preview into potential therapeutic targets.

Original language	English (US)
Title of host publication	Intervertebral Disc Degeneration
Subtitle of host publication	Prevalence, Risk Factors and Treatments
Publisher	Nova Science Publishers, Inc.
Pages	1-16
Number of pages	16
ISBN (Electronic)	9781634858571
ISBN (Print)	9781634858298
State	Published - Jan 1 2016

ASJC Scopus subject areas

Medicine(all)

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AB - The degeneration of the intervertebral disc results from several multifactorial pathophysiologic processes. Here, we discuss the anatomy of the intervertebral disc along with a presentation of several pathologic processes including vascular insufficiency (possibly due to cigarette exposure and endothelial dysfunction), anatomic variations, poor nutritional status, infections, autoimmune and/or inflammatory processes, genetic predispositions and iatrogenic occurrences as well as exposure to drugs or toxins that lead to degeneration of the disc. This brief overview establishes a necessary starting point for the understanding of these processes as well as a preview into potential therapeutic targets.

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