The pathophysiology of intervertebral disc disease

Akwasi Ofori Boah, Nancy Abu-Bonsrah, C. Rory Goodwin, Daniel Sciubba

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The degeneration of the intervertebral disc results from several multifactorial pathophysiologic processes. Here, we discuss the anatomy of the intervertebral disc along with a presentation of several pathologic processes including vascular insufficiency (possibly due to cigarette exposure and endothelial dysfunction), anatomic variations, poor nutritional status, infections, autoimmune and/or inflammatory processes, genetic predispositions and iatrogenic occurrences as well as exposure to drugs or toxins that lead to degeneration of the disc. This brief overview establishes a necessary starting point for the understanding of these processes as well as a preview into potential therapeutic targets.

Original languageEnglish (US)
Title of host publicationIntervertebral Disc Degeneration
Subtitle of host publicationPrevalence, Risk Factors and Treatments
PublisherNova Science Publishers, Inc.
Pages1-16
Number of pages16
ISBN (Electronic)9781634858571
ISBN (Print)9781634858298
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Medicine(all)

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    Boah, A. O., Abu-Bonsrah, N., Goodwin, C. R., & Sciubba, D. (2016). The pathophysiology of intervertebral disc disease. In Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments (pp. 1-16). Nova Science Publishers, Inc..