Abstract
An intermediate trophoblast is a distinctive trophoblastic cell population from which four trophoblastic lesions are thought to arise: exaggerated placental site (EPS), placental site nodule (PSN), placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). EPSs and PSTTs are related to the differentiation of the intermediate trophoblast in the implantation site (implantation site inter-mediate trophoblast), whereas PSNs and ETTs are related to the intermediate trophoblast of the chorion laeve (chorionic-type intermediate trophoblast). EPSs and PSNs are nonneoplastic lesions, whereas PSTTs and ETTs are neoplasms with a potential for local invasion and metastasis. Microscopically, intermediate trophoblastic lesions can be confused with a variety of trophoblastic and nontrophoblastic tumors, but an appreciation of the morphologic features and immunophenotype allows their diagnosis to be relatively straightforward in most instances. Correct diagnosis is important because each of these lesions may require different therapeutic approaches.
Original language | English (US) |
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Pages (from-to) | 31-47 |
Number of pages | 17 |
Journal | International Journal of Gynecological Pathology |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
Keywords
- Epithelioid trophoblastic tumor
- Intermediate trophoblast
- Placental site nodule
- Placental site trophoblastic tumor
- Trophoblast
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Obstetrics and Gynecology