The pathogenicity of nonenterotoxigenic vibrio cholerae serogroup 01 biotype ei tor isolated from sewage water in brazil

M. M. Levine, R. E. Black, M. L. Clements, L. Cisneros, A. Saah, D. R. Nalin, D. M. Gill, J. P. Craig, C. R. Young, P. Ristaino

Research output: Contribution to journalArticlepeer-review

Abstract

Nonenterotoxigenic strains no. 1196-78 and no. 1074-78 of Vibrio cholerae serogroup 01 (biotype EI Tor, serotype Ogawa) were isolated from sewage water in Brazil and fed to 20 volunteers. Neither strain caused diarrhea. None of the seven volunteers who ingested Ogawa strain no. 1074-78(106 organisms) excreted the organism whereas eight of the 13 volunteers who ingested Ogawa strain no. 1196-78 (106 or 108 organisms) did excrete the organism in their stools. None of 114 stool-culture isolates yielded cholera enterotoxin, and none of the 20 volunteers had significant increases in serum titers of antitoxin as measured by enzyme-linked immunosorbent assay although six of the volunteers had slightly elevated vibriocidal antibody levels. Six volunteers used as controls and four volunteers who had stool cultures positive for strain no. 11%-78 of V. cholerae were challenged with pathogenic EI Tor Ogawa strain no. E7946 (1Q6 organisms) to determine if previous ingestion of the Brazilian strain would induce protective immunity. All 10 of the volunteers developed diarrhea, and the severity of the illness was similar in both groups.

Original languageEnglish (US)
Pages (from-to)296-299
Number of pages4
JournalJournal of Infectious Diseases
Volume145
Issue number3
DOIs
StatePublished - Mar 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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