The Paradox of Muscle Hypertrophy in Muscular Dystrophy

Joe N. Kornegay, Martin K. Childers, Daniel J. Bogan, Janet R. Bogan, Peter Nghiem, Jiahui Wang, Zheng Fan, James F. Howard, Scott J. Schatzberg, Jennifer L. Dow, Robert W. Grange, Martin A. Styner, Eric P. Hoffman, Kathryn Rae Wagner

Research output: Contribution to journalArticle

Abstract

Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophy in humans and syndromes in mice, dogs, and cats. Affected humans and dogs have progressive disease that leads primarily to muscle atrophy. Mdx mice progress through an initial phase of muscle hypertrophy followed by atrophy. Cats have persistent muscle hypertrophy. Hypertrophy in humans has been attributed to deposition of fat and connective tissue (pseudohypertrophy). Increased muscle mass (true hypertrophy) has been documented in animal models. Muscle hypertrophy can exaggerate postural instability and joint contractures. Deleterious consequences of muscle hypertrophy should be considered when developing treatments for muscular dystrophy.

Original languageEnglish (US)
Pages (from-to)149-172
Number of pages24
JournalPhysical Medicine and Rehabilitation Clinics of North America
Volume23
Issue number1
DOIs
StatePublished - Feb 2012

Fingerprint

Muscular Dystrophies
Hypertrophy
Muscles
Cats
Dogs
Inbred mdx Mouse
Joint Instability
Dystrophin
Muscular Atrophy
Duchenne Muscular Dystrophy
Contracture
Connective Tissue
Atrophy
Animal Models
Fats
Mutation
Genes

Keywords

  • DMD
  • GRMD
  • Muscle hypertrophy
  • Muscular dystrophy

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

The Paradox of Muscle Hypertrophy in Muscular Dystrophy. / Kornegay, Joe N.; Childers, Martin K.; Bogan, Daniel J.; Bogan, Janet R.; Nghiem, Peter; Wang, Jiahui; Fan, Zheng; Howard, James F.; Schatzberg, Scott J.; Dow, Jennifer L.; Grange, Robert W.; Styner, Martin A.; Hoffman, Eric P.; Wagner, Kathryn Rae.

In: Physical Medicine and Rehabilitation Clinics of North America, Vol. 23, No. 1, 02.2012, p. 149-172.

Research output: Contribution to journalArticle

Kornegay, JN, Childers, MK, Bogan, DJ, Bogan, JR, Nghiem, P, Wang, J, Fan, Z, Howard, JF, Schatzberg, SJ, Dow, JL, Grange, RW, Styner, MA, Hoffman, EP & Wagner, KR 2012, 'The Paradox of Muscle Hypertrophy in Muscular Dystrophy', Physical Medicine and Rehabilitation Clinics of North America, vol. 23, no. 1, pp. 149-172. https://doi.org/10.1016/j.pmr.2011.11.014
Kornegay, Joe N. ; Childers, Martin K. ; Bogan, Daniel J. ; Bogan, Janet R. ; Nghiem, Peter ; Wang, Jiahui ; Fan, Zheng ; Howard, James F. ; Schatzberg, Scott J. ; Dow, Jennifer L. ; Grange, Robert W. ; Styner, Martin A. ; Hoffman, Eric P. ; Wagner, Kathryn Rae. / The Paradox of Muscle Hypertrophy in Muscular Dystrophy. In: Physical Medicine and Rehabilitation Clinics of North America. 2012 ; Vol. 23, No. 1. pp. 149-172.
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