The oxygen equilibrium of the hybrids of canine and human haemoglobin

Eraldo Antonini, Jeffries Wyman, Enrico Bucci, Clara Fronticelli, Maurizio Brunori, Morris Reichlin, Alessandro Rossi Fanelli

Research output: Contribution to journalArticle

Abstract

Hybrids of human A1 and canine haemoglobins have been prepared, namely Hbα2Aβ2Ca and Hbα2Caß2A, and the oxygen equilibria have been studied in comparison with those of the parent molecules. The behaviour of the α2Caß2A hybrid is similar to that of the parent molecules (which are both much alike), although the reverse Bohr effect is somewhat increased. In contrast the α2Aß2Ca hybrid has no reverse Bohr effect, lower oxygen affinity (especially at pH

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalBiochimica et Biophysica Acta - General Subjects
Volume104
Issue number1
StatePublished - Jun 15 1965
Externally publishedYes

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Canidae
Hemoglobins
Oxygen
Molecules

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry
  • Medicine(all)

Cite this

Antonini, E., Wyman, J., Bucci, E., Fronticelli, C., Brunori, M., Reichlin, M., & Rossi Fanelli, A. (1965). The oxygen equilibrium of the hybrids of canine and human haemoglobin. Biochimica et Biophysica Acta - General Subjects, 104(1), 160-166.

The oxygen equilibrium of the hybrids of canine and human haemoglobin. / Antonini, Eraldo; Wyman, Jeffries; Bucci, Enrico; Fronticelli, Clara; Brunori, Maurizio; Reichlin, Morris; Rossi Fanelli, Alessandro.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 104, No. 1, 15.06.1965, p. 160-166.

Research output: Contribution to journalArticle

Antonini, E, Wyman, J, Bucci, E, Fronticelli, C, Brunori, M, Reichlin, M & Rossi Fanelli, A 1965, 'The oxygen equilibrium of the hybrids of canine and human haemoglobin', Biochimica et Biophysica Acta - General Subjects, vol. 104, no. 1, pp. 160-166.
Antonini E, Wyman J, Bucci E, Fronticelli C, Brunori M, Reichlin M et al. The oxygen equilibrium of the hybrids of canine and human haemoglobin. Biochimica et Biophysica Acta - General Subjects. 1965 Jun 15;104(1):160-166.
Antonini, Eraldo ; Wyman, Jeffries ; Bucci, Enrico ; Fronticelli, Clara ; Brunori, Maurizio ; Reichlin, Morris ; Rossi Fanelli, Alessandro. / The oxygen equilibrium of the hybrids of canine and human haemoglobin. In: Biochimica et Biophysica Acta - General Subjects. 1965 ; Vol. 104, No. 1. pp. 160-166.
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