The oxygen Bohr effect of human fetal hemoglobin

Eraldo Antonini, Jeffries Wyman, Maurizio Brunori, Clara Fronticelli, Enrico Bucci, Morris Reichlin, Alessandro Rossi Fanelli

Research output: Contribution to journalArticlepeer-review

Abstract

The oxygen Bohr effect of human fetal hemoglobin has been studied both in terms of oxygen equilibrium at constant pH and of differential titrations. Fetal and adult hemoglobins have the same normal but different reverse Bohr effects, the reverse effect in fetal hemoglobin being only about half that of adult hemoglobin. The heme-heme interactions are the same for the two proteins, the value of n being equal to 2.9 ± 0.2 over the entire pH range examined.

Original languageEnglish (US)
Pages (from-to)569-572
Number of pages4
JournalArchives of Biochemistry and Biophysics
Volume108
Issue number3
DOIs
StatePublished - Dec 1964
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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