The oxygen Bohr effect of human fetal hemoglobin

Eraldo Antonini; Jeffries Wyman; Maurizio Brunori; Clara Fronticelli; Enrico Bucci; Morris Reichlin; Alessandro Rossi Fanelli

doi:10.1016/0003-9861(64)90443-6

The oxygen Bohr effect of human fetal hemoglobin

Eraldo Antonini, Jeffries Wyman, Maurizio Brunori, Clara Fronticelli, Enrico Bucci, Morris Reichlin, Alessandro Rossi Fanelli

Research output: Contribution to journal › Article › peer-review

Abstract

The oxygen Bohr effect of human fetal hemoglobin has been studied both in terms of oxygen equilibrium at constant pH and of differential titrations. Fetal and adult hemoglobins have the same normal but different reverse Bohr effects, the reverse effect in fetal hemoglobin being only about half that of adult hemoglobin. The heme-heme interactions are the same for the two proteins, the value of n being equal to 2.9 ± 0.2 over the entire pH range examined.

Original language	English (US)
Pages (from-to)	569-572
Number of pages	4
Journal	Archives of Biochemistry and Biophysics
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/0003-9861(64)90443-6
State	Published - Dec 1964
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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title = "The oxygen Bohr effect of human fetal hemoglobin",

abstract = "The oxygen Bohr effect of human fetal hemoglobin has been studied both in terms of oxygen equilibrium at constant pH and of differential titrations. Fetal and adult hemoglobins have the same normal but different reverse Bohr effects, the reverse effect in fetal hemoglobin being only about half that of adult hemoglobin. The heme-heme interactions are the same for the two proteins, the value of n being equal to 2.9 ± 0.2 over the entire pH range examined.",

author = "Eraldo Antonini and Jeffries Wyman and Maurizio Brunori and Clara Fronticelli and Enrico Bucci and Morris Reichlin and Fanelli, {Alessandro Rossi}",

note = "Funding Information: I This work was supported in part by a grant from the National Science Foundation to J.W. *Recipient of a U. S. Public Health Service Fellowship (I-F2-HE-20) and Fellowship 729-01 from the National Heart Institute.",

year = "1964",

month = dec,

doi = "10.1016/0003-9861(64)90443-6",

language = "English (US)",

volume = "108",

pages = "569--572",

journal = "Archives of Biochemistry and Biophysics",

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T1 - The oxygen Bohr effect of human fetal hemoglobin

AU - Antonini, Eraldo

AU - Wyman, Jeffries

AU - Brunori, Maurizio

AU - Fronticelli, Clara

AU - Bucci, Enrico

AU - Reichlin, Morris

AU - Fanelli, Alessandro Rossi

N1 - Funding Information: I This work was supported in part by a grant from the National Science Foundation to J.W. *Recipient of a U. S. Public Health Service Fellowship (I-F2-HE-20) and Fellowship 729-01 from the National Heart Institute.

PY - 1964/12

Y1 - 1964/12

N2 - The oxygen Bohr effect of human fetal hemoglobin has been studied both in terms of oxygen equilibrium at constant pH and of differential titrations. Fetal and adult hemoglobins have the same normal but different reverse Bohr effects, the reverse effect in fetal hemoglobin being only about half that of adult hemoglobin. The heme-heme interactions are the same for the two proteins, the value of n being equal to 2.9 ± 0.2 over the entire pH range examined.

AB - The oxygen Bohr effect of human fetal hemoglobin has been studied both in terms of oxygen equilibrium at constant pH and of differential titrations. Fetal and adult hemoglobins have the same normal but different reverse Bohr effects, the reverse effect in fetal hemoglobin being only about half that of adult hemoglobin. The heme-heme interactions are the same for the two proteins, the value of n being equal to 2.9 ± 0.2 over the entire pH range examined.

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The oxygen Bohr effect of human fetal hemoglobin

Abstract

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