The ovarian hyperstimulation syndrome

Joseph G. Whelan, Nikos F. Vlahos

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: To review the up-to-date literature concerning the pathogenesis of, risk factors for, prevention of, and therapy for the ovarian hyperstimulation syndrome, and to provide suggestions for management of this syndrome. Design: Literature review combined with on-site clinical experiences at the authors' institution of practice. Patient(s): Women who have risk factors for or manifest the ovarian hyperstimulation syndrome. Intervention(s): Intravenous fluid management, thrombosis prevention techniques, paracentesis techniques, and critical care management protocols. Main Outcome Measure(s): Staging system of the ovarian hyperstimulation syndrome, criteria for outpatient versus hospitalization management, and indications for varying levels of interventional management. Result(s): The ovarian hyperstimulation syndrome, unique to the field of assisted reproductive technology, remains a largely elusive and unpredictable iatrogenic physiologic complication in the course of pharmacologic ovarian stimulation. Reliable information on risk factors, possible physiologic mechanisms, prevention techniques, and management is fortunately progressing, and overall advances are being made in this field. The present review is an attempt to summarize the modern literature regarding this syndrome and to use this current knowledge to provide a basis for acceptable management regimens. Conclusion(s): Ovarian hyperstimulation syndrome is a serious complication of assisted reproductive technology, with potential for critical morbidity and death. Physicians who prescribe medications known to be associated with this syndrome should be familiar with identifiable risk factors, means of prevention, and a system for staging and treating the disease and have a current knowledge base for putative models of pathogenesis. (C)2000 by American Society for Reproductive Medicine.

    Original languageEnglish (US)
    Pages (from-to)883-896
    Number of pages14
    JournalFertility and sterility
    Volume73
    Issue number5
    DOIs
    StatePublished - May 2000

    Keywords

    • Assisted reproductive technologies
    • Controlled ovarian hyperstimulation
    • In vitro fertilization
    • Ovarian hyperstimulation syndrome
    • Ovulation induction
    • Paracentesis
    • Polycystic ovarian syndrome

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

    Fingerprint Dive into the research topics of 'The ovarian hyperstimulation syndrome'. Together they form a unique fingerprint.

    Cite this