The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus

Laura A. Schrader, Anne E. Anderson, Andrew W. Varga, Michael Levy, J. David Sweatt

Research output: Contribution to journalReview articlepeer-review

Abstract

Historically, much attention has focused on the mechanisms of activity-dependent plasticity since the description of long-term potentiation by Bliss and Lomo in the early 1970s, while extrasynaptic changes have received much less interest. However, recent work has concentrated on the role of back-propagating action potentials in hippocampal dendrites in synaptic plasticity. In this review, we focus on the modulation of back-propagating action potentials by K+ currents in the dendrites of hippocampal cells. We described the primary K+-channel subunits and their interacting subunits that most likely contribute to these currents, and how these sites can be regulated by phosphorylation and other mechanisms. In conclusion, we provide a model for an alternative form of coincidence detection through K+ channels in the hippocampus.

Original languageEnglish (US)
Pages (from-to)51-66
Number of pages16
JournalMolecular Neurobiology
Volume25
Issue number1
StatePublished - Jan 1 2002

Keywords

  • Extrasynaptic
  • Hebbian
  • Kv4.2
  • LTP
  • Learning
  • Memory
  • Metaplasticity
  • Neuromodulation
  • Shal
  • Suprasynaptic

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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