The osmolality of nasal secretions increases when inflammatory mediators are released in response to inhalation of cold, dry air

A. G. Togias, D. Proud, L. M. Lichtenstein, G. K. Adams, P. S. Norman, A. Kagey-Sobotka, R. M. Naclerio

Research output: Contribution to journalArticle

Abstract

Inhaling cold, dry air nasally induces in some persons symptoms of rhinitis that are associated with an increase in the level of mast-cell-associated mediators in nasal lavages. The present study, directed at understanding the mechanisms of this reaction, showed that 9 subjects who displayed symptoms and inflammatory mediator release had significant (p<0.01) increments in nasal fluid osmolality, whereas the osmolality of the fluids of 6 subjects unaffected by cold, dry air challenge did not differ from baseline. Significant correlations were found between the mediator concentration and the osmolality of recovered nasal lavages (R(s) = 0.617, p < 0.02; r(s) = 0.679, p < 0.01 for histamine and TAME-esterase(s), respectively). No changes in the osmolality of nasal secretions were found in atopic subjects undergoing nasal challenge with antigen, despite the generation of symptoms and significant elevations in the levels of inflammatory mediators in their nasal lavages. Because increasing the osmolality of the medium surrounding isolated mast cells in vitro triggers mediator secretion, these observations support the concept that the response to cold, dry air nasal inhalation is caused by the release of mediators secondary to an increase in the osmolality of the mucosal secretions.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume137
Issue number3
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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