The optic nerve: A new window into cerebrospinal fluid composition?

H. E. Killer, G. P. Jaggi, J. Flammer, N. R. Miller, A. R. Huber

Research output: Contribution to journalArticlepeer-review


Cerebrospinal fluid (CSF) pressure and composition are generally thought to be homogeneous within small limits throughout all CSF compartments. CSF sampled during lumbar puncture therefore should be representative for all CSF compartments. On the basis of clinical findings, histology and biochemical markers, we present for the first time strong evidence that the subarachnoid spaces (SAS) of the optic nerve (ON) can become separated from other CSF compartments in certain ON disorders, thus leading to an ON sheath compartment syndrome. This may result in an abnormal concentration gradient of CSF molecular markers determined in locally sampled CSF compared with CSF taken during lumbar puncture.

Original languageEnglish (US)
Pages (from-to)1027-1030
Number of pages4
Issue number4
StatePublished - Apr 2006


  • Beta trace protein
  • Cerebrospinal fluid
  • Optic nerve
  • Subarachnoid space

ASJC Scopus subject areas

  • Clinical Neurology


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