An opiate receptor has been described and found to assume different conformations in order to accomodate both exogenous and 'endogenous' opiates. These 'endogenous' opiates represent a new class of neuropeptides, the endorphins. Their structure has been isolated, and their activity is beginning to be understood. The opiates and the endorphins are intimately related to the mechanism of pain and the induction of analgesia. Preliminary investigations indicate that greater understanding of such diverse clinical areas as schizophrenia, anesthesiology, drug abuse, and the affective disorders may result from the knowledge of these new classes of compounds.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Dec 1 1979|
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