The opiate receptor: a model explaining structure activity relationships of opiate agonists and antagonists

Research output: Contribution to journalArticlepeer-review

Abstract

A model of the opiate receptor is proposed which explains structure activity relationships of opiate drugs, including (i) the unique potency of certain opiates such as etonitazene, fentanyl, phenazocine, and oripavines; (ii) the role of N allyl substituents in conferring antagonist properties; (iii) chemical features that afford 'pure' antagonists. The model indicates molecular mechanisms for interconversion of the opiate receptor between respective states that bind agonists or antagonists with high affinity.

Original languageEnglish (US)
Pages (from-to)4215-4219
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number11
DOIs
StatePublished - 1976

ASJC Scopus subject areas

  • General

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