Abstract
A model of the opiate receptor is proposed which explains structure activity relationships of opiate drugs, including (i) the unique potency of certain opiates such as etonitazene, fentanyl, phenazocine, and oripavines; (ii) the role of N allyl substituents in conferring antagonist properties; (iii) chemical features that afford 'pure' antagonists. The model indicates molecular mechanisms for interconversion of the opiate receptor between respective states that bind agonists or antagonists with high affinity.
Original language | English (US) |
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Pages (from-to) | 4215-4219 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 73 |
Issue number | 11 |
DOIs | |
State | Published - 1976 |
ASJC Scopus subject areas
- General