The opiate receptor

S. H. Snyder, C. B. Pert, G. W. Pasternak

Research output: Contribution to journalArticlepeer-review

Abstract

Binding of radioactive opiates and opiate antagonists to the opiate receptor in the brain and other tissues can be shown. This binding mediates the pharmacologic effects of the drugs. The regional distribution of the opiate receptor in monkey and human brain parallels the motivational affective pathways of pain perception and comprises several limbic system structures. In subcellular fractionation experiments, the opiate receptor is localized to synaptic membranes. The influence of sodium on receptor binding permits predictions of the extent to which a drug possesses opiate agonist, antagonist, or mixed properties. The simple, sensitive and specific opiate receptor binding assay facilitates development of pure opiate antagonists for treating narcotic addiction and mixed agonist antagonist agents with potential as nonaddicting analgesics.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalAnnals of internal medicine
Volume81
Issue number4
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Internal Medicine

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