The opiate receptor

S. H. Snyder; C. B. Pert; G. W. Pasternak

doi:10.7326/0003-4819-81-4-534

The opiate receptor

S. H. Snyder, C. B. Pert, G. W. Pasternak

School of Medicine

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Binding of radioactive opiates and opiate antagonists to the opiate receptor in the brain and other tissues can be shown. This binding mediates the pharmacologic effects of the drugs. The regional distribution of the opiate receptor in monkey and human brain parallels the motivational affective pathways of pain perception and comprises several limbic system structures. In subcellular fractionation experiments, the opiate receptor is localized to synaptic membranes. The influence of sodium on receptor binding permits predictions of the extent to which a drug possesses opiate agonist, antagonist, or mixed properties. The simple, sensitive and specific opiate receptor binding assay facilitates development of pure opiate antagonists for treating narcotic addiction and mixed agonist antagonist agents with potential as nonaddicting analgesics.

Original language	English (US)
Pages (from-to)	534-540
Number of pages	7
Journal	Annals of internal medicine
Volume	81
Issue number	4
DOIs	https://doi.org/10.7326/0003-4819-81-4-534
State	Published - Jan 1 1974

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.7326/0003-4819-81-4-534

Cite this

@article{40c156c676e84f0eaf9c407e0ded2964,

title = "The opiate receptor",

abstract = "Binding of radioactive opiates and opiate antagonists to the opiate receptor in the brain and other tissues can be shown. This binding mediates the pharmacologic effects of the drugs. The regional distribution of the opiate receptor in monkey and human brain parallels the motivational affective pathways of pain perception and comprises several limbic system structures. In subcellular fractionation experiments, the opiate receptor is localized to synaptic membranes. The influence of sodium on receptor binding permits predictions of the extent to which a drug possesses opiate agonist, antagonist, or mixed properties. The simple, sensitive and specific opiate receptor binding assay facilitates development of pure opiate antagonists for treating narcotic addiction and mixed agonist antagonist agents with potential as nonaddicting analgesics.",

author = "Snyder, {S. H.} and Pert, {C. B.} and Pasternak, {G. W.}",

year = "1974",

month = jan,

day = "1",

doi = "10.7326/0003-4819-81-4-534",

language = "English (US)",

volume = "81",

pages = "534--540",

journal = "Annals of internal medicine",

issn = "0003-4819",

publisher = "American College of Physicians",

number = "4",

}

TY - JOUR

T1 - The opiate receptor

AU - Snyder, S. H.

AU - Pert, C. B.

AU - Pasternak, G. W.

PY - 1974/1/1

Y1 - 1974/1/1

N2 - Binding of radioactive opiates and opiate antagonists to the opiate receptor in the brain and other tissues can be shown. This binding mediates the pharmacologic effects of the drugs. The regional distribution of the opiate receptor in monkey and human brain parallels the motivational affective pathways of pain perception and comprises several limbic system structures. In subcellular fractionation experiments, the opiate receptor is localized to synaptic membranes. The influence of sodium on receptor binding permits predictions of the extent to which a drug possesses opiate agonist, antagonist, or mixed properties. The simple, sensitive and specific opiate receptor binding assay facilitates development of pure opiate antagonists for treating narcotic addiction and mixed agonist antagonist agents with potential as nonaddicting analgesics.

AB - Binding of radioactive opiates and opiate antagonists to the opiate receptor in the brain and other tissues can be shown. This binding mediates the pharmacologic effects of the drugs. The regional distribution of the opiate receptor in monkey and human brain parallels the motivational affective pathways of pain perception and comprises several limbic system structures. In subcellular fractionation experiments, the opiate receptor is localized to synaptic membranes. The influence of sodium on receptor binding permits predictions of the extent to which a drug possesses opiate agonist, antagonist, or mixed properties. The simple, sensitive and specific opiate receptor binding assay facilitates development of pure opiate antagonists for treating narcotic addiction and mixed agonist antagonist agents with potential as nonaddicting analgesics.

UR - http://www.scopus.com/inward/record.url?scp=0016205795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016205795&partnerID=8YFLogxK

U2 - 10.7326/0003-4819-81-4-534

DO - 10.7326/0003-4819-81-4-534

M3 - Article

C2 - 4213465

AN - SCOPUS:0016205795

SN - 0003-4819

VL - 81

SP - 534

EP - 540

JO - Annals of internal medicine

JF - Annals of internal medicine

IS - 4

ER -

The opiate receptor

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this