The 'open artery hypothesis' in survivors of myocardial infarction

William R. Pitts, Joaquin E. Cigarroa, Richard A. Lange, L. David Hillis

Research output: Contribution to journalArticle

Abstract

In survivors of acute myocardial infarction, the restoration of antegrade flow in the infarct-related coronary artery may improve prognosis by a mechanism independent of its effect on left ventricular function. Survival may be enhanced even when restoration of flow is accomplished days or weeks after the acute event. In a series of retrospective studies of survivors of a first myocardial infarction, it was shown that long-term survival is significantly better in those with than in those without antegrade flow in the infarct-related artery. It is hypothesized that late restoration of antegrade flow in the infarct-related artery renders the border zone of the infarction more electrically stable, thereby diminishing the incidence of ventricular tachyarrhythmias and sudden death.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalClinical Cardiology
Volume20
Issue number6
StatePublished - 1997
Externally publishedYes

Fingerprint

Arteries
Myocardial Infarction
Sudden Death
Left Ventricular Function
Tachycardia
Infarction
Coronary Vessels
Retrospective Studies
Incidence

Keywords

  • Infarct artery
  • Patency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pitts, W. R., Cigarroa, J. E., Lange, R. A., & David Hillis, L. (1997). The 'open artery hypothesis' in survivors of myocardial infarction. Clinical Cardiology, 20(6), 522-524.

The 'open artery hypothesis' in survivors of myocardial infarction. / Pitts, William R.; Cigarroa, Joaquin E.; Lange, Richard A.; David Hillis, L.

In: Clinical Cardiology, Vol. 20, No. 6, 1997, p. 522-524.

Research output: Contribution to journalArticle

Pitts, WR, Cigarroa, JE, Lange, RA & David Hillis, L 1997, 'The 'open artery hypothesis' in survivors of myocardial infarction', Clinical Cardiology, vol. 20, no. 6, pp. 522-524.
Pitts WR, Cigarroa JE, Lange RA, David Hillis L. The 'open artery hypothesis' in survivors of myocardial infarction. Clinical Cardiology. 1997;20(6):522-524.
Pitts, William R. ; Cigarroa, Joaquin E. ; Lange, Richard A. ; David Hillis, L. / The 'open artery hypothesis' in survivors of myocardial infarction. In: Clinical Cardiology. 1997 ; Vol. 20, No. 6. pp. 522-524.
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