The ontogeny of the androgen receptor in human foreskin

K. R. Fichman, L. M. Nyberg, P. Bujnovszky, T. R. Brown, Patrick Walsh

Research output: Contribution to journalArticle

Abstract

To investigate the relationship between the androgen receptor content of human foreskin and age-dependent physiological changes in genital development, cytosolic and nuclear androgen receptors were measured in preputial skin specimens from male subjects of various ages. Optimum incubation conditions (4 C, 20 h) were established for measurement of androgen receptors by the exchange method with the synthetic androgen ligand methyltrinolone. The number of total androgen receptor sites, cytosolic plus nuclear, was fairly constant at all ages studied. However, the androgen receptor was predominantly localized to the nuclear compartment at those developmental stages characterized by higher levels of circulating blood androgens, i.e. newborns, pubertal males, and adults. By contrast, the androgen receptor in specimens from prepubertal boys was confined almost exclusively to the cytosolic compartment. This corresponds to a time of low plasma androgen levels and quiescence in genital maturation. It is suggested that changes in the intracellular distribution of androgen receptors may bear some relationship to the sequence of normal genital growth and development with nuclear androgen receptors having major physiological importance.

Original languageEnglish (US)
Pages (from-to)919-923
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume52
Issue number5
StatePublished - 1981

Fingerprint

Foreskin
Androgen Receptors
Cytoplasmic and Nuclear Receptors
Androgens
Testosterone Congeners
human AR protein
Growth and Development
Skin
Blood
Newborn Infant
Ligands
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Fichman, K. R., Nyberg, L. M., Bujnovszky, P., Brown, T. R., & Walsh, P. (1981). The ontogeny of the androgen receptor in human foreskin. Journal of Clinical Endocrinology and Metabolism, 52(5), 919-923.

The ontogeny of the androgen receptor in human foreskin. / Fichman, K. R.; Nyberg, L. M.; Bujnovszky, P.; Brown, T. R.; Walsh, Patrick.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 52, No. 5, 1981, p. 919-923.

Research output: Contribution to journalArticle

Fichman, KR, Nyberg, LM, Bujnovszky, P, Brown, TR & Walsh, P 1981, 'The ontogeny of the androgen receptor in human foreskin', Journal of Clinical Endocrinology and Metabolism, vol. 52, no. 5, pp. 919-923.
Fichman, K. R. ; Nyberg, L. M. ; Bujnovszky, P. ; Brown, T. R. ; Walsh, Patrick. / The ontogeny of the androgen receptor in human foreskin. In: Journal of Clinical Endocrinology and Metabolism. 1981 ; Vol. 52, No. 5. pp. 919-923.
@article{9610582f68cc4dda89044df0f7db226e,
title = "The ontogeny of the androgen receptor in human foreskin",
abstract = "To investigate the relationship between the androgen receptor content of human foreskin and age-dependent physiological changes in genital development, cytosolic and nuclear androgen receptors were measured in preputial skin specimens from male subjects of various ages. Optimum incubation conditions (4 C, 20 h) were established for measurement of androgen receptors by the exchange method with the synthetic androgen ligand methyltrinolone. The number of total androgen receptor sites, cytosolic plus nuclear, was fairly constant at all ages studied. However, the androgen receptor was predominantly localized to the nuclear compartment at those developmental stages characterized by higher levels of circulating blood androgens, i.e. newborns, pubertal males, and adults. By contrast, the androgen receptor in specimens from prepubertal boys was confined almost exclusively to the cytosolic compartment. This corresponds to a time of low plasma androgen levels and quiescence in genital maturation. It is suggested that changes in the intracellular distribution of androgen receptors may bear some relationship to the sequence of normal genital growth and development with nuclear androgen receptors having major physiological importance.",
author = "Fichman, {K. R.} and Nyberg, {L. M.} and P. Bujnovszky and Brown, {T. R.} and Patrick Walsh",
year = "1981",
language = "English (US)",
volume = "52",
pages = "919--923",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - The ontogeny of the androgen receptor in human foreskin

AU - Fichman, K. R.

AU - Nyberg, L. M.

AU - Bujnovszky, P.

AU - Brown, T. R.

AU - Walsh, Patrick

PY - 1981

Y1 - 1981

N2 - To investigate the relationship between the androgen receptor content of human foreskin and age-dependent physiological changes in genital development, cytosolic and nuclear androgen receptors were measured in preputial skin specimens from male subjects of various ages. Optimum incubation conditions (4 C, 20 h) were established for measurement of androgen receptors by the exchange method with the synthetic androgen ligand methyltrinolone. The number of total androgen receptor sites, cytosolic plus nuclear, was fairly constant at all ages studied. However, the androgen receptor was predominantly localized to the nuclear compartment at those developmental stages characterized by higher levels of circulating blood androgens, i.e. newborns, pubertal males, and adults. By contrast, the androgen receptor in specimens from prepubertal boys was confined almost exclusively to the cytosolic compartment. This corresponds to a time of low plasma androgen levels and quiescence in genital maturation. It is suggested that changes in the intracellular distribution of androgen receptors may bear some relationship to the sequence of normal genital growth and development with nuclear androgen receptors having major physiological importance.

AB - To investigate the relationship between the androgen receptor content of human foreskin and age-dependent physiological changes in genital development, cytosolic and nuclear androgen receptors were measured in preputial skin specimens from male subjects of various ages. Optimum incubation conditions (4 C, 20 h) were established for measurement of androgen receptors by the exchange method with the synthetic androgen ligand methyltrinolone. The number of total androgen receptor sites, cytosolic plus nuclear, was fairly constant at all ages studied. However, the androgen receptor was predominantly localized to the nuclear compartment at those developmental stages characterized by higher levels of circulating blood androgens, i.e. newborns, pubertal males, and adults. By contrast, the androgen receptor in specimens from prepubertal boys was confined almost exclusively to the cytosolic compartment. This corresponds to a time of low plasma androgen levels and quiescence in genital maturation. It is suggested that changes in the intracellular distribution of androgen receptors may bear some relationship to the sequence of normal genital growth and development with nuclear androgen receptors having major physiological importance.

UR - http://www.scopus.com/inward/record.url?scp=0019759423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019759423&partnerID=8YFLogxK

M3 - Article

C2 - 7228995

AN - SCOPUS:0019759423

VL - 52

SP - 919

EP - 923

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -