The ontogeny of 3,4-dihydroxyphenylacetic acid in human cerebrospinal fluid

G. M. Anderson; M. A. Riddle; E. L. Hoder; F. C. Feibel; B. A. Shaywitz; D. J. Cohen

doi:10.1136/jnnp.51.8.1100

The ontogeny of 3,4-dihydroxyphenylacetic acid in human cerebrospinal fluid

G. M. Anderson, M. A. Riddle, E. L. Hoder, F. C. Feibel, B. A. Shaywitz, D. J. Cohen

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Measurement of cerebrospinal fluid (CSF) levels of the minor dopamine metabolite 3,4-dihydroxyphenylacetic acid in neonates and children indicates that a rapid decline (approximately 90%) occurs in the first 2 years of life. The much less rapid ontogenetic decline seen for the predominant dopamine metabolite, homovanillic acid (HVA), indicates that differing factors affect CSF levels of the two acid metabolites. Further study is required to determine which compound more closely reflects ontogenetic changes in dopamine functioning.

Original language	English (US)
Pages (from-to)	1100-1102
Number of pages	3
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	51
Issue number	8
DOIs	https://doi.org/10.1136/jnnp.51.8.1100
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Surgery
Clinical Neurology
Psychiatry and Mental health

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AU - Anderson, G. M.

AU - Riddle, M. A.

AU - Hoder, E. L.

AU - Feibel, F. C.

AU - Shaywitz, B. A.

AU - Cohen, D. J.

PY - 1988

Y1 - 1988

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AB - Measurement of cerebrospinal fluid (CSF) levels of the minor dopamine metabolite 3,4-dihydroxyphenylacetic acid in neonates and children indicates that a rapid decline (approximately 90%) occurs in the first 2 years of life. The much less rapid ontogenetic decline seen for the predominant dopamine metabolite, homovanillic acid (HVA), indicates that differing factors affect CSF levels of the two acid metabolites. Further study is required to determine which compound more closely reflects ontogenetic changes in dopamine functioning.

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ER -

The ontogeny of 3,4-dihydroxyphenylacetic acid in human cerebrospinal fluid

Abstract

ASJC Scopus subject areas

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