The ontogeny of 3,4-dihydroxyphenylacetic acid in human cerebrospinal fluid

G. M. Anderson, M. A. Riddle, E. L. Hoder, F. C. Feibel, B. A. Shaywitz, D. J. Cohen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Measurement of cerebrospinal fluid (CSF) levels of the minor dopamine metabolite 3,4-dihydroxyphenylacetic acid in neonates and children indicates that a rapid decline (approximately 90%) occurs in the first 2 years of life. The much less rapid ontogenetic decline seen for the predominant dopamine metabolite, homovanillic acid (HVA), indicates that differing factors affect CSF levels of the two acid metabolites. Further study is required to determine which compound more closely reflects ontogenetic changes in dopamine functioning.

Original languageEnglish (US)
Pages (from-to)1100-1102
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number8
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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