The ongoing evolution of proteomics in malignancy

Amit S. Dhamoon, Elise C. Kohn, Nilofer S. Azad

Research output: Contribution to journalReview article

Abstract

The complementary fields of genomics and proteomics offer insights into the molecular mechanisms of diseases. While genomics seeks to define our genetic substrate, proteomics explores the structure and function of proteins, which are the end effectors of our genes. Proteomics has been revolutionized in the past decade by the application of techniques such as protein arrays, two-dimensional gel electrophoresis, and mass spectrometry. These techniques have tremendous potential for biomarker development, target validation, diagnosis, prognosis, and optimization of treatment in medical care, especially in the field of clinical oncology. We will discuss innovations in proteomic technologies and highlight their prospective applications to patient care.

Original languageEnglish (US)
Pages (from-to)700-708
Number of pages9
JournalDrug Discovery Today
Volume12
Issue number17-18
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'The ongoing evolution of proteomics in malignancy'. Together they form a unique fingerprint.

  • Cite this