The oncogenic properties of the HMG-I gene family

L. J. Wood, J. F. Maher, T. E. Bunton, L. M.S. Resar

Research output: Contribution to journalArticle

Abstract

The HMG-I gene family encodes high mobility group proteins originally identified as nonhistone chromosomal binding proteins. HMG-I and -Y proteins are alternatively spliced products of the same mRNA; HMG-C is encoded by a separate gene. The HMG-I proteins function as architectural chromatin-binding proteins that bind to the narrow groove of AT-rich regions in double-stranded DNA. Recent studies indicate an important role for HMG-I proteins in regulating gene expression. Moreover, increased expression of the HMG-I, -Y, and -C proteins correlates with cellular proliferation and neoplastic transformation in several cell types and human cancers. Previous work from our laboratory has shown that HMG-I is a direct c-Myc target gene that is involved in Myc-mediated neoplastic transformation. In this report, we show that increased expression of HMG-Y or -C leads to transformation with anchorage-independent cell growth in two experimental cell lines in a manner similar to that of HMG-I or c-Myc. Moreover, Rat 1a cells overexpressing HMG-Y or -C form tumors in nude mice analogous to Rat 1a cells overexpressing HMG-I or c-Myc. Distant metastases developed in animals injected with cells overexpressing HMG-I or -C. Our findings suggest that the HMG-I gene family is involved in neoplastic transformation and may represent a new family of oncogenes important in the pathogenesis of several human cancers.

Original languageEnglish (US)
Pages (from-to)4256-4261
Number of pages6
JournalCancer Research
Volume60
Issue number15
StatePublished - Aug 31 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The oncogenic properties of the HMG-I gene family'. Together they form a unique fingerprint.

  • Cite this

    Wood, L. J., Maher, J. F., Bunton, T. E., & Resar, L. M. S. (2000). The oncogenic properties of the HMG-I gene family. Cancer Research, 60(15), 4256-4261.