The “oldest and coldest” shipped living donor kidneys transplanted through kidney paired donation

Nima Nassiri, Lorna Kwan, Aswani Bolagani, Alvin G. Thomas, Joseph Sinacore, Matthew Ronin, Matthew Cooper, Dorry Segev, J. Michael Cecka, Jeffrey L. Veale

Research output: Contribution to journalArticle

Abstract

To date, thousands of living donor kidneys have been shipped through kidney paired donation (KPD). To expand on this growing segment of living donor transplantation, we evaluated the effect of advanced age donation (“oldest kidneys”) and prolonged cold ischemia time (“coldest kidneys”) on graft function and survival using the National Kidney Registry database from February 2008 to May 2018. Donors were stratified by age at time of donation (<65 or ≥65 years) and kidneys were stratified by cold ischemia time (<16 or ≥16 hours). We evaluated delayed graft function and death-censored graft failure (DCGF) for up to seven posttransplant years. Of the 2363 shipped living donor kidney transplants, 4.1% of donors were ≥65 years and 6.0% of transplanted kidneys had cold ischemia times ≥16 hours. Delayed graft function and DCGF occurred in 5.2% and 4.7% of cases. There were no significant associations between delayed graft function and donor age (P =.947) or cold ischemia (P =.532). Donor age and cold ischemia time were not predictive of delayed graft function (OR = 0.86,1.20; P =.8,.6) or DCGF (HR = 1.38,0.35, P =.5,.1). These findings may alleviate concerns surrounding the utilization of kidneys from older donors or those originating from distant transplant centers.

Original languageEnglish (US)
JournalAmerican Journal of Transplantation
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Living Donors
Cold Ischemia
Kidney
Delayed Graft Function
Tissue Donors
Transplants
Graft Survival
Registries
Transplantation
Databases

Keywords

  • clinical research/practice
  • donors and donation
  • donors and donation: living
  • donors and donation: paired exchange
  • kidney transplantation/nephrology
  • organ procurement and allocation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Nassiri, N., Kwan, L., Bolagani, A., Thomas, A. G., Sinacore, J., Ronin, M., ... Veale, J. L. (Accepted/In press). The “oldest and coldest” shipped living donor kidneys transplanted through kidney paired donation. American Journal of Transplantation. https://doi.org/10.1111/ajt.15527

The “oldest and coldest” shipped living donor kidneys transplanted through kidney paired donation. / Nassiri, Nima; Kwan, Lorna; Bolagani, Aswani; Thomas, Alvin G.; Sinacore, Joseph; Ronin, Matthew; Cooper, Matthew; Segev, Dorry; Michael Cecka, J.; Veale, Jeffrey L.

In: American Journal of Transplantation, 01.01.2019.

Research output: Contribution to journalArticle

Nassiri, N, Kwan, L, Bolagani, A, Thomas, AG, Sinacore, J, Ronin, M, Cooper, M, Segev, D, Michael Cecka, J & Veale, JL 2019, 'The “oldest and coldest” shipped living donor kidneys transplanted through kidney paired donation', American Journal of Transplantation. https://doi.org/10.1111/ajt.15527
Nassiri, Nima ; Kwan, Lorna ; Bolagani, Aswani ; Thomas, Alvin G. ; Sinacore, Joseph ; Ronin, Matthew ; Cooper, Matthew ; Segev, Dorry ; Michael Cecka, J. ; Veale, Jeffrey L. / The “oldest and coldest” shipped living donor kidneys transplanted through kidney paired donation. In: American Journal of Transplantation. 2019.
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