Since vitamin A has been shown to be necessary for normal differentiation and maintenance of mucus secreting epithelia, it is of interest to investigate whether vitamin A is also required for the maintenance of chemically induced mucinous adenocarcinomas of the small intestine. For this purpose, the authors determined the levels of retinyl esters and retinol in the mucinous adenocarcinomas of the intestine of Fischer rats and compared them with the normal intestinal mucosa. Retinyl esters and retinol were determined by a modification of the spectrofluorometric method by Thompson et al. Preliminary data indicate that in mucinous adenocarcinomas, the concentrations of retinyl esters and retinol are 100.5 and 28.5 ng. per gm. wet weight respectively. In the normal intestinal mucosa, the concentrations of retinyl esters and retinol are 103.6 and 30.3 ng. per gm. wet weight.
|Original language||English (US)|
|Number of pages||1|
|Issue number||3 I|
|State||Published - Jan 1 1974|
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