The nucleus basalis of Meynert, senile plaques, and intellectual impairment in schizophrenia

R. S. El-Mallakh; D. G. Kirch; R. Shelton; K. J. Fan; G. Pezeshkpour; S. Kanhouwa; R. J. Wyatt; J. E. Kleinman

doi:10.1176/jnp.3.4.383

The nucleus basalis of Meynert, senile plaques, and intellectual impairment in schizophrenia

R. S. El-Mallakh, D. G. Kirch, R. Shelton, K. J. Fan, G. Pezeshkpour, S. Kanhouwa, R. J. Wyatt, J. E. Kleinman

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The large, hyperchromic, cholinergic neurons of the nucleus basalis of Meynert (nbM) and the presence of senile plaques were quantified in postmortem brain tissue from 10 intellectually impaired schizophrenic patients, seven intellectually intact schizophrenic patients, seven control subjects, and three patients with Alzheimer's disease. The two groups of schizophrenic patients did not show any significant differences when compared with the control group in nbM cell density or in plaque frequency. The Alzheimer's disease patients showed the expected decrease in nbM neuronal density and increase in plaques compared with the controls. The data suggest that compromised cognitive function in schizophrenia is not associated with diffuse neuropathology of the basal forebrain cholinergic system.

Original language	English (US)
Pages (from-to)	383-386
Number of pages	4
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	3
Issue number	4
DOIs	https://doi.org/10.1176/jnp.3.4.383
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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title = "The nucleus basalis of Meynert, senile plaques, and intellectual impairment in schizophrenia",

abstract = "The large, hyperchromic, cholinergic neurons of the nucleus basalis of Meynert (nbM) and the presence of senile plaques were quantified in postmortem brain tissue from 10 intellectually impaired schizophrenic patients, seven intellectually intact schizophrenic patients, seven control subjects, and three patients with Alzheimer's disease. The two groups of schizophrenic patients did not show any significant differences when compared with the control group in nbM cell density or in plaque frequency. The Alzheimer's disease patients showed the expected decrease in nbM neuronal density and increase in plaques compared with the controls. The data suggest that compromised cognitive function in schizophrenia is not associated with diffuse neuropathology of the basal forebrain cholinergic system.",

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AU - Kirch, D. G.

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AU - Fan, K. J.

AU - Pezeshkpour, G.

AU - Kanhouwa, S.

AU - Wyatt, R. J.

AU - Kleinman, J. E.

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The nucleus basalis of Meynert, senile plaques, and intellectual impairment in schizophrenia

Abstract

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