TY - JOUR
T1 - The nucleoskeleton as a genome-associated dynamic 'network of networks'
AU - Simon, Dan N.
AU - Wilson, Katherine L.
N1 - Funding Information:
We thank J. M. Berk for comments. We apologize to authors whose works could not be cited owing to space limitations. We gratefully acknowledge support from the US National Institutes of Health (RO1 GM48646 to K.L.W.).
PY - 2011/11
Y1 - 2011/11
N2 - In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to the nucleus through LINC (links the nucleoskeleton and cytoskeleton) complexes that span the nuclear envelope and in turn anchor to networks of filaments in the nucleus. The metazoan nucleoskeleton includes nuclear pore-linked filaments, A-type and B-type lamin intermediate filaments, nuclear mitotic apparatus (NuMA) networks, spectrins, titin, 'unconventional' polymers of actin and at least ten different myosin and kinesin motors. These elements constitute a poorly understood 'network of networks' that dynamically reorganizes during mitosis and is responsible for genome organization and integrity.
AB - In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to the nucleus through LINC (links the nucleoskeleton and cytoskeleton) complexes that span the nuclear envelope and in turn anchor to networks of filaments in the nucleus. The metazoan nucleoskeleton includes nuclear pore-linked filaments, A-type and B-type lamin intermediate filaments, nuclear mitotic apparatus (NuMA) networks, spectrins, titin, 'unconventional' polymers of actin and at least ten different myosin and kinesin motors. These elements constitute a poorly understood 'network of networks' that dynamically reorganizes during mitosis and is responsible for genome organization and integrity.
UR - http://www.scopus.com/inward/record.url?scp=80054902318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054902318&partnerID=8YFLogxK
U2 - 10.1038/nrm3207
DO - 10.1038/nrm3207
M3 - Review article
C2 - 21971041
AN - SCOPUS:80054902318
VL - 12
SP - 695
EP - 708
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
SN - 1471-0072
IS - 11
ER -