The nucleoskeleton as a genome-associated dynamic 'network of networks'

Dan N. Simon, Katherine L. Wilson

Research output: Contribution to journalReview articlepeer-review


In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to the nucleus through LINC (links the nucleoskeleton and cytoskeleton) complexes that span the nuclear envelope and in turn anchor to networks of filaments in the nucleus. The metazoan nucleoskeleton includes nuclear pore-linked filaments, A-type and B-type lamin intermediate filaments, nuclear mitotic apparatus (NuMA) networks, spectrins, titin, 'unconventional' polymers of actin and at least ten different myosin and kinesin motors. These elements constitute a poorly understood 'network of networks' that dynamically reorganizes during mitosis and is responsible for genome organization and integrity.

Original languageEnglish (US)
Pages (from-to)695-708
Number of pages14
JournalNature Reviews Molecular Cell Biology
Issue number11
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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