The nuclear lamina comes of age

Yosef Gruenbaum, Ayelet Margalit, Robert D. Goldman, Dale K. Shumaker, Katherine L. Wilson

Research output: Contribution to journalReview articlepeer-review

Abstract

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins, nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, gene regulation and signal transduction. Some link the nucleoskeleton to cytoskeletal structures, ensuring that the nucleus and centrosome assume appropriate intracellular positions. These complexes provide new insights into cell architecture, as well as a foundation for the understanding of the molecular mechanisms that underlie the human laminopathies - clinical disorders that range from Emery-Dreifuss muscular dystrophy to the accelerated ageing seen in Hutchinson-Gilford progeria syndrome.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
JournalNature Reviews Molecular Cell Biology
Volume6
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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