The nuclear envelope, muscular dystrophy and gene expression

Research output: Contribution to journalArticlepeer-review

191 Scopus citations


Lamins and other nuclear envelope proteins organize nuclear architecture through structural attachments that vary dynamically during the cell cycle and cell differentiation. Genetic studies have now shown that people with mutations in either lamins A/C or emerin, a nuclear membrane protein, develop Emery-Dreifuss muscular dystrophy. A mouse model for this rare disease has been created by knocking out the gene that encodes lamin A/C. This article discusses these and other recent results in the wider context of nuclear envelope function, as a framework for thinking about the possible ways in which defects in nuclear envelope proteins can lead to disease. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalTrends in Cell Biology
Issue number4
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Cell Biology


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