TY - JOUR
T1 - The nuclear envelope, muscular dystrophy and gene expression
AU - Wilson, Katherine L.
N1 - Funding Information:
I apologize to the many authors whose work could not be cited directly. Many thanks to colleagues Burke, Craigie, Dabauvalle, Ellis, Foisner, Gruenbaum, Morris, Rapoport and Worman for sharing unpublished information. I thank K. Lee, C. Machamer, R. Jensen, C. Greider, Y. Gruenbaum and D. Shumaker for critical reading of the manuscript. I am grateful to Ray Mills and his family for sharing the human side of EDMD and the hope that basic research will lead to clinical therapy. Work in my laboratory is funded by the WW Smith Charitable Trust.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000/4/1
Y1 - 2000/4/1
N2 - Lamins and other nuclear envelope proteins organize nuclear architecture through structural attachments that vary dynamically during the cell cycle and cell differentiation. Genetic studies have now shown that people with mutations in either lamins A/C or emerin, a nuclear membrane protein, develop Emery-Dreifuss muscular dystrophy. A mouse model for this rare disease has been created by knocking out the gene that encodes lamin A/C. This article discusses these and other recent results in the wider context of nuclear envelope function, as a framework for thinking about the possible ways in which defects in nuclear envelope proteins can lead to disease. Copyright (C) 2000 Elsevier Science Ltd.
AB - Lamins and other nuclear envelope proteins organize nuclear architecture through structural attachments that vary dynamically during the cell cycle and cell differentiation. Genetic studies have now shown that people with mutations in either lamins A/C or emerin, a nuclear membrane protein, develop Emery-Dreifuss muscular dystrophy. A mouse model for this rare disease has been created by knocking out the gene that encodes lamin A/C. This article discusses these and other recent results in the wider context of nuclear envelope function, as a framework for thinking about the possible ways in which defects in nuclear envelope proteins can lead to disease. Copyright (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0962-8924(99)01708-0
DO - 10.1016/S0962-8924(99)01708-0
M3 - Article
C2 - 10740265
AN - SCOPUS:0034176682
VL - 10
SP - 125
EP - 129
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 4
ER -