The nuclear envelope LEM-domain protein emerin

Jason M. Berk, Kathryn E. Tifft, Katherine L. Wilson

Research output: Contribution to journalReview article

Abstract

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge- biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease- is available. This review summarizes emerin and its emerging roles in nuclear "lamina" structure, chromatin tethering, gene regulation, mitosis, nuclear assembly, development, signaling and mechano-transduction. We also highlight many open questions, exploration of which will be critical to understand how this intriguing nuclear membrane protein and its "family" influence the genome.

Original languageEnglish (US)
JournalNucleus (United States)
Volume4
Issue number4
DOIs
StatePublished - Jul 2013

Keywords

  • Barrier-to-Autointegration Factor
  • Emerin
  • Emery-Dreifuss muscular dystrophy
  • GAGE cancer-testis antigen
  • LEM-domain
  • Laminopathy
  • Nestor-Guillermo progeria
  • Nuclear envelope
  • Nucleoskeleton
  • O-GlcNAc transferase

ASJC Scopus subject areas

  • Cell Biology

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