The nuclear envelope, lamins and nuclear assembly

James M. Holaska, Katherine Lee Wilson, Malini Mansharamani

Research output: Contribution to journalArticle

Abstract

The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins. Many lamin-binding proteins are integral proteins of the inner nuclear membrane. Lamins and inner nuclear membrane proteins are important for a variety of cell functions, including nuclear assembly, replication, transcription, and nuclear integrity. Recent advances in the field in the past year include the identification of a family of spectrin-repeat-containing inner nuclear membrane proteins and other novel inner-membrane proteins, and the discovery of a nuclear membrane fusion complex. There is also growing evidence that A- and B-type lamins and their binding partners have distinct roles during nuclear assembly and interphase.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2002

Fingerprint

Lamins
Nuclear Envelope
Lamin Type B
Lamin Type A
Membrane Proteins
Nuclear Proteins
Carrier Proteins
Nuclear Fusion
Nuclear Lamina
Spectrin
Membrane Fusion
Interphase
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

The nuclear envelope, lamins and nuclear assembly. / Holaska, James M.; Wilson, Katherine Lee; Mansharamani, Malini.

In: Current Opinion in Cell Biology, Vol. 14, No. 3, 01.06.2002, p. 357-364.

Research output: Contribution to journalArticle

Holaska, James M. ; Wilson, Katherine Lee ; Mansharamani, Malini. / The nuclear envelope, lamins and nuclear assembly. In: Current Opinion in Cell Biology. 2002 ; Vol. 14, No. 3. pp. 357-364.
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