The nuclear envelope, lamins and nuclear assembly

James M. Holaska, Katherine L. Wilson, Malini Mansharamani

Research output: Contribution to journalReview article

Abstract

The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins. Many lamin-binding proteins are integral proteins of the inner nuclear membrane. Lamins and inner nuclear membrane proteins are important for a variety of cell functions, including nuclear assembly, replication, transcription, and nuclear integrity. Recent advances in the field in the past year include the identification of a family of spectrin-repeat-containing inner nuclear membrane proteins and other novel inner-membrane proteins, and the discovery of a nuclear membrane fusion complex. There is also growing evidence that A- and B-type lamins and their binding partners have distinct roles during nuclear assembly and interphase.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Cell Biology

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