The novel inflammatory marker GlycA and the prevalence and progression of valvular and thoracic aortic calcification: The Multi-Ethnic Study of Atherosclerosis

Angelica Ezeigwe, Oluwaseun E. Fashanu, Di Zhao, Matthew J. Budoff, James D. Otvos, Isac C. Thomas, Samia Mora, Martin Tibuakuu, Erin D. Michos

Research output: Contribution to journalArticle

Abstract

Background and aims: GlycA is a novel composite biomarker of systemic inflammation reflecting posttranslational glycosylation of acute phase reactants. GlycA has been associated with coronary artery calcium, cardiovascular disease (CVD) events and mortality. Vascular calcifications outside of the coronary arteries are risk markers of CVD and mortality. Whether GlycA is linked to extra-coronary calcifications (ECC) is not well established. Methods: We studied 6462 MESA participants free of clinical CVD who had plasma GlycA measured at baseline. ECCs [calcification in aortic valve (AVC), mitral annulus (MAC), ascending and descending thoracic aorta (ATAC, DTAC)] were ascertained at baseline and follow-up visit (median 2.3-yrs later) by cardiac CT. Poisson regression models with robust variance estimation assessed associations of GlycA with prevalent and incident ECC. Linear mixed models assessed the cross-sectional and 2-year change in ECC. Models were adjusted for demographic and lifestyle factors. Results: In cross-sectional analysis, GlycA (per SD increment) was positively associated with prevalent AVC, ATAC and DTAC with adjusted prevalence ratios (95% CI) of 1.08 (1.01–1.14), 1.18 (1.03–1.34) and 1.10 (1.06–1.14), respectively. There was also a significant association between GlycA and baseline extent of both ATAC and DTAC. Longitudinally, GlycA was positively associated with incident MAC and DTAC, with adjusted incidence ratios of 1.18 (1.03–1.37) and 1.17 (1.07–1.28), respectively. GlycA was also associated with 2-year change in MAC and DTAC extent. Conclusions: In this diverse cohort free from clinical CVD, we found GlycA was positively associated with prevalent and incident ECC measures, in particular for progression of MAC and DTAC.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalAtherosclerosis
Volume282
DOIs
StatePublished - Mar 2019

Keywords

  • Aortic valve calcification
  • GlycA
  • Inflammation
  • Mitral annular calcification
  • Thoracic aortic calcification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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