The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association with Roseola

Thomas Cristoforo, Nicole K. Le, Summer Rye-Buckingham, William B. Hudson, Leslie F. Carroll

Research output: Contribution to journalArticlepeer-review

Abstract

Roseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6-induced cytokine elevation leading to increased cerebrospinal fluid production.

Original languageEnglish (US)
Pages (from-to)E576-E578
JournalPediatric emergency care
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2020

Keywords

  • CSF
  • cytokines
  • HHV-6
  • intracranial hypertension

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine

Fingerprint Dive into the research topics of 'The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association with Roseola'. Together they form a unique fingerprint.

Cite this