The nhlbi twin study of cardiovascular disease risk factors: Methodology and summary of results

M. Feinleib, R. J. Garrison, R. Fabsitz, J. C. Christian, Z. Hrubec, N. O. Borhani, W. B. Kannel, R. Rosenman, J. T. Schwartz, J. O. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

Feinleib, M. (National Heart, Lung, and Blood institute, NIH, Federal Bldg., Room 2C08, Bethesda, MD 20014), R. J. Garrison, R. Fabsitz, J. C. Christian, Z. Hrubec, N. O. Borhani, W. B. Kannel, R. Rosenman, J. T. Schwartz and J. O. Wagner. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol 106:284-295, 1977.Coronary heart disease (CHD) risk factors were studied in 250 monozygotic (MZ) and 264 dizygotic (DZ) male veteran twin pairs, aged 42-56. All coronary heart disease risk factors studied showed significant correlations in both MZ and DZ twins. Substantial genetic variation was detected for height, blood pressure, glucose intolerance, uric acid, plasma triglyceride, and relative weight but little or no significant genetic variability in low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), total plasma cholesterol or hematocrit was demonstrable. These findings suggest that familial aggregation results from genetic influence on blood pressure, glucose intolerance, uric acid, triglyceride and, possibly, obesity, while largely shared environmental factors contribute to familial similarities in HDL, LDL, total cholesterol and hematocrit.

Original languageEnglish (US)
Pages (from-to)284-295
Number of pages12
JournalAmerican Journal of Epidemiology
Volume106
Issue number4
StatePublished - Oct 1977
Externally publishedYes

Keywords

  • Blood pressure
  • Cholesterol
  • Coronary heart disease
  • Genetics
  • Glucose tolerance
  • Twins
  • Uric acid

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

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