TY - JOUR
T1 - The nhlbi twin study of cardiovascular disease risk factors
T2 - Methodology and summary of results
AU - Feinleib, M.
AU - Garrison, R. J.
AU - Fabsitz, R.
AU - Christian, J. C.
AU - Hrubec, Z.
AU - Borhani, N. O.
AU - Kannel, W. B.
AU - Rosenman, R.
AU - Schwartz, J. T.
AU - Wagner, J. O.
PY - 1977/10
Y1 - 1977/10
N2 - Feinleib, M. (National Heart, Lung, and Blood institute, NIH, Federal Bldg., Room 2C08, Bethesda, MD 20014), R. J. Garrison, R. Fabsitz, J. C. Christian, Z. Hrubec, N. O. Borhani, W. B. Kannel, R. Rosenman, J. T. Schwartz and J. O. Wagner. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol 106:284-295, 1977.Coronary heart disease (CHD) risk factors were studied in 250 monozygotic (MZ) and 264 dizygotic (DZ) male veteran twin pairs, aged 42-56. All coronary heart disease risk factors studied showed significant correlations in both MZ and DZ twins. Substantial genetic variation was detected for height, blood pressure, glucose intolerance, uric acid, plasma triglyceride, and relative weight but little or no significant genetic variability in low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), total plasma cholesterol or hematocrit was demonstrable. These findings suggest that familial aggregation results from genetic influence on blood pressure, glucose intolerance, uric acid, triglyceride and, possibly, obesity, while largely shared environmental factors contribute to familial similarities in HDL, LDL, total cholesterol and hematocrit.
AB - Feinleib, M. (National Heart, Lung, and Blood institute, NIH, Federal Bldg., Room 2C08, Bethesda, MD 20014), R. J. Garrison, R. Fabsitz, J. C. Christian, Z. Hrubec, N. O. Borhani, W. B. Kannel, R. Rosenman, J. T. Schwartz and J. O. Wagner. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol 106:284-295, 1977.Coronary heart disease (CHD) risk factors were studied in 250 monozygotic (MZ) and 264 dizygotic (DZ) male veteran twin pairs, aged 42-56. All coronary heart disease risk factors studied showed significant correlations in both MZ and DZ twins. Substantial genetic variation was detected for height, blood pressure, glucose intolerance, uric acid, plasma triglyceride, and relative weight but little or no significant genetic variability in low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), total plasma cholesterol or hematocrit was demonstrable. These findings suggest that familial aggregation results from genetic influence on blood pressure, glucose intolerance, uric acid, triglyceride and, possibly, obesity, while largely shared environmental factors contribute to familial similarities in HDL, LDL, total cholesterol and hematocrit.
KW - Blood pressure
KW - Cholesterol
KW - Coronary heart disease
KW - Genetics
KW - Glucose tolerance
KW - Twins
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=0017761036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017761036&partnerID=8YFLogxK
M3 - Article
C2 - 562066
AN - SCOPUS:0017761036
SN - 0002-9262
VL - 106
SP - 284
EP - 295
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 4
ER -