The NF-κB family in learning and memory

C. K. Shrum, M. K. Meffert

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The nuclear factor kappa B (NFκB) transcription factors are expressed in all cells of the central nervous system where they are activated by physiological as well as pathological stimuli. This chapter discusses the role of NFκB in mechanisms of plasticity within the brain and its unique function in neurons as a transcription factor that can localize in dendrites and at synapses. A requirement for NFκB in the regulation of cognitive processes such as learning and memory appears conserved across species from invertebrates to mammals. NFκB can be activated by excitatory neurotransmission, and its capacity to reciprocally regulate genes with potential impact on synaptic strength and plasticity is now emerging.

Original languageEnglish (US)
Title of host publicationLearning and Memory
Subtitle of host publicationA Comprehensive Reference
PublisherElsevier
Pages567-585
Number of pages19
ISBN (Electronic)9780123705099
DOIs
StatePublished - Jan 1 2007

Keywords

  • CNS
  • Calcium
  • Cognition
  • Dendrite
  • Gene expression
  • Glutamate
  • Learning
  • Memory
  • NFκB
  • Neuron
  • Synapse
  • Transcription

ASJC Scopus subject areas

  • Medicine(all)

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    Shrum, C. K., & Meffert, M. K. (2007). The NF-κB family in learning and memory. In Learning and Memory: A Comprehensive Reference (pp. 567-585). Elsevier. https://doi.org/10.1016/B978-012370509-9.00031-0