The new XCAT series of digital phantoms for multi-modality imaging

W. Paul Segars, Gregory M. Sturgeon, Daniel J. Ward, J. Tilak Ratnanather, Michael I. Miller, B. M.W. Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed a series of 4D Extended Cardiac-Torso (XCAT) phantoms for multimodality imaging research. Highly detailed whole-body anatomies for the initial adult male and female were previously defined for the XCAT using nonuniform rational b-spline (NURBS) surfaces based on the Visible Male and Female anatomical datasets from the National Library of Medicine. To extend the XCAT beyond these adult models, we utilized innovative methods in computational anatomy to efficiently create new phantoms by mapping the template XCAT anatomy (male or female) to match the anatomical framework provided by patient CT data. We applied these methods to create a series of 4D XCAT phantoms representing both genders with varying ages, heights, and weights from pediatric to adult patients. Forty-seven phantoms were created in total, 25 male and 22 female, each containing thousands of anatomical objects. To demonstrate the usefulness of the phantoms, we show example simulation studies in PET, SPECT, and CT using publicly available simulation packages. As demonstrated in the pilot studies, the 4D XCAT series can produce realistic imaging data when combined with accurate models of the imaging process. Distributed to the research community, such a unique library of computational models will have a widespread use in imaging research to quantitatively evaluate and improve imaging devices and techniques and to investigate the effects of anatomy and motion.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Pages2392-2395
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States
Duration: Oct 30 2010Nov 6 2010

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
CountryUnited States
CityKnoxville, TN
Period10/30/1011/6/10

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ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Segars, W. P., Sturgeon, G. M., Ward, D. J., Ratnanather, J. T., Miller, M. I., & Tsui, B. M. W. (2010). The new XCAT series of digital phantoms for multi-modality imaging. In IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010 (pp. 2392-2395). [5874215] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2010.5874215