TY - GEN
T1 - The new XCAT series of digital phantoms for multi-modality imaging
AU - Segars, W. Paul
AU - Sturgeon, Gregory M.
AU - Ward, Daniel J.
AU - Ratnanather, J. Tilak
AU - Miller, Michael I.
AU - Tsui, Benjamin
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - We developed a series of 4D Extended Cardiac-Torso (XCAT) phantoms for multimodality imaging research. Highly detailed whole-body anatomies for the initial adult male and female were previously defined for the XCAT using nonuniform rational b-spline (NURBS) surfaces based on the Visible Male and Female anatomical datasets from the National Library of Medicine. To extend the XCAT beyond these adult models, we utilized innovative methods in computational anatomy to efficiently create new phantoms by mapping the template XCAT anatomy (male or female) to match the anatomical framework provided by patient CT data. We applied these methods to create a series of 4D XCAT phantoms representing both genders with varying ages, heights, and weights from pediatric to adult patients. Forty-seven phantoms were created in total, 25 male and 22 female, each containing thousands of anatomical objects. To demonstrate the usefulness of the phantoms, we show example simulation studies in PET, SPECT, and CT using publicly available simulation packages. As demonstrated in the pilot studies, the 4D XCAT series can produce realistic imaging data when combined with accurate models of the imaging process. Distributed to the research community, such a unique library of computational models will have a widespread use in imaging research to quantitatively evaluate and improve imaging devices and techniques and to investigate the effects of anatomy and motion.
AB - We developed a series of 4D Extended Cardiac-Torso (XCAT) phantoms for multimodality imaging research. Highly detailed whole-body anatomies for the initial adult male and female were previously defined for the XCAT using nonuniform rational b-spline (NURBS) surfaces based on the Visible Male and Female anatomical datasets from the National Library of Medicine. To extend the XCAT beyond these adult models, we utilized innovative methods in computational anatomy to efficiently create new phantoms by mapping the template XCAT anatomy (male or female) to match the anatomical framework provided by patient CT data. We applied these methods to create a series of 4D XCAT phantoms representing both genders with varying ages, heights, and weights from pediatric to adult patients. Forty-seven phantoms were created in total, 25 male and 22 female, each containing thousands of anatomical objects. To demonstrate the usefulness of the phantoms, we show example simulation studies in PET, SPECT, and CT using publicly available simulation packages. As demonstrated in the pilot studies, the 4D XCAT series can produce realistic imaging data when combined with accurate models of the imaging process. Distributed to the research community, such a unique library of computational models will have a widespread use in imaging research to quantitatively evaluate and improve imaging devices and techniques and to investigate the effects of anatomy and motion.
UR - http://www.scopus.com/inward/record.url?scp=79960297205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960297205&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2010.5874215
DO - 10.1109/NSSMIC.2010.5874215
M3 - Conference contribution
AN - SCOPUS:79960297205
SN - 9781424491063
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2392
EP - 2395
BT - IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
Y2 - 30 October 2010 through 6 November 2010
ER -