The new revolution in toxicology: The good, the bad, and the ugly

Myrtle Davis, Kim Boekelheide, Darrell R. Boverhof, Gary Eichenbaum, Thomas Hartung, Michael P. Holsapple, Thomas W. Jones, Ann M. Richard, Paul B. Watkins

Research output: Contribution to journalArticle

Abstract

In 2007, the United States National Academy of Sciences issued a report entitled Toxicity Testing in the 21st Century: A Vision and a Strategy. The report reviewed the state of the science and outlined a strategy for the future of toxicity testing. One of the more significant components of the vision established by the report was an emphasis on toxicity testing in human rather than animal systems. In the context of drug development, it is critical that the tools used to accomplish this strategy are maximally capable of evaluating human risk. Since 2007, many advances toward implementation of this vision have been achieved, particularly with regard to safety assessment of new chemical entities intended for pharmaceutical use.

Original languageEnglish (US)
Pages (from-to)11-24
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1278
Issue number1
DOIs
StatePublished - Mar 2013

Keywords

  • Pharmaceuticals
  • Testing
  • Toxicology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Davis, M., Boekelheide, K., Boverhof, D. R., Eichenbaum, G., Hartung, T., Holsapple, M. P., Jones, T. W., Richard, A. M., & Watkins, P. B. (2013). The new revolution in toxicology: The good, the bad, and the ugly. Annals of the New York Academy of Sciences, 1278(1), 11-24. https://doi.org/10.1111/nyas.12086