The neuropathogenesis of visna virus infection in sheep

Mary Christine Zink, M. D. Gorrell, O. Narayan

Research output: Contribution to journalArticle

Abstract

Visna virus is a lentivirus which causes chronic, progressive encephalitis in sheep. The virus is highly tropic for cells of the monocyte/macrophage lineage and completion of the viral replicative cycle occurs only in mature macrophages. Combined immunohistochemistry and in situ hybridization studies have demonstrated an association between the number of infected macrophages in the brain and the severity of the lesions. A neurovirulent visna virus strain, developed by multiple sequential intracerebral passages in sheep, had an enhanced ability to replicate in macrophages. Visna virus-infected animals produce several cytokines, one of which augments inflammation by inducing expression of MHC class II antigens on macrophages.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalSeminars in the Neurosciences
Volume3
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Visna-maedi virus
Virus Diseases
Sheep
Macrophages
Lentivirus
Histocompatibility Antigens Class II
Encephalitis
In Situ Hybridization
Monocytes
Immunohistochemistry
Cytokines
Viruses
Inflammation
Brain

Keywords

  • cytokines
  • macrophage tropism
  • neuropathogenesis
  • visna

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The neuropathogenesis of visna virus infection in sheep. / Zink, Mary Christine; Gorrell, M. D.; Narayan, O.

In: Seminars in the Neurosciences, Vol. 3, No. 2, 1991, p. 125-130.

Research output: Contribution to journalArticle

Zink, Mary Christine ; Gorrell, M. D. ; Narayan, O. / The neuropathogenesis of visna virus infection in sheep. In: Seminars in the Neurosciences. 1991 ; Vol. 3, No. 2. pp. 125-130.
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