TY - JOUR
T1 - The neurologic basis of fever
AU - Flier, Jeffrey S.
AU - Underhill, Lisa H.
AU - Saper, Clifford B.
AU - Breder, Christopher D.
PY - 1994/6/30
Y1 - 1994/6/30
N2 - Fever is a complex, coordinated autonomic, neuroendocrine, and behavioral response that is adaptive and is used by nearly all vertebrates as part of the acute-phase reaction to immune challenge. Although the febrile response can be elicited by a wide variety of infectious organisms and may also occur during noninfectious inflammatory conditions, its manifestations are stereotyped and largely independent of the causative agent. Like other integrated responses, such as the regulation of energy metabolism, blood pressure and volume, and reproduction, fever depends on humoral cues from the body, is orchestrated largely by the hypothalamus, and involves the coordination of a wide.
AB - Fever is a complex, coordinated autonomic, neuroendocrine, and behavioral response that is adaptive and is used by nearly all vertebrates as part of the acute-phase reaction to immune challenge. Although the febrile response can be elicited by a wide variety of infectious organisms and may also occur during noninfectious inflammatory conditions, its manifestations are stereotyped and largely independent of the causative agent. Like other integrated responses, such as the regulation of energy metabolism, blood pressure and volume, and reproduction, fever depends on humoral cues from the body, is orchestrated largely by the hypothalamus, and involves the coordination of a wide.
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U2 - 10.1056/NEJM199406303302609
DO - 10.1056/NEJM199406303302609
M3 - Review article
C2 - 7832832
AN - SCOPUS:0028782669
SN - 0028-4793
VL - 330
SP - 1880
EP - 1886
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 26
ER -