Several neurohumoral substances, which cause active electrolyte secretion or inhibit absorption in rabbit ileum but do not affect the adenylate cyclase-CAMP system, were shown to increase Ca++ influx across the serosal surface of rabbit ileum and also to increase total ileal calcium content. These neurohumoral substances include carbachol, substance P and neurotensin. It is possible that many neurohumoral substances which cause similar changes in ileal electrolyte transport act by increasing the basolateral membrane permeability to Ca++.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)