The neurohumoral secretagogues carbachol, substance P and neurotensin increase Ca++ influx and calcium content in rabbit ileum

Mark Donowitz, Ronald Fogel, Laurie Battisti, Nancy Asarkof

Research output: Contribution to journalArticle

Abstract

Several neurohumoral substances, which cause active electrolyte secretion or inhibit absorption in rabbit ileum but do not affect the adenylate cyclase-CAMP system, were shown to increase Ca++ influx across the serosal surface of rabbit ileum and also to increase total ileal calcium content. These neurohumoral substances include carbachol, substance P and neurotensin. It is possible that many neurohumoral substances which cause similar changes in ileal electrolyte transport act by increasing the basolateral membrane permeability to Ca++.

Original languageEnglish (US)
Pages (from-to)1929-1937
Number of pages9
JournalLife Sciences
Volume31
Issue number18
DOIs
StatePublished - Nov 1 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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