The neurohumoral secretagogues carbachol, substance P and neurotensin increase Ca++ influx and calcium content in rabbit ileum

Mark Donowitz; Ronald Fogel; Laurie Battisti; Nancy Asarkof

doi:10.1016/0024-3205(82)90031-5

The neurohumoral secretagogues carbachol, substance P and neurotensin increase Ca⁺⁺ influx and calcium content in rabbit ileum

Mark Donowitz, Ronald Fogel, Laurie Battisti, Nancy Asarkof

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Several neurohumoral substances, which cause active electrolyte secretion or inhibit absorption in rabbit ileum but do not affect the adenylate cyclase-CAMP system, were shown to increase Ca⁺⁺ influx across the serosal surface of rabbit ileum and also to increase total ileal calcium content. These neurohumoral substances include carbachol, substance P and neurotensin. It is possible that many neurohumoral substances which cause similar changes in ileal electrolyte transport act by increasing the basolateral membrane permeability to Ca⁺⁺.

Original language	English (US)
Pages (from-to)	1929-1937
Number of pages	9
Journal	Life Sciences
Volume	31
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(82)90031-5
State	Published - Nov 1 1982
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "Several neurohumoral substances, which cause active electrolyte secretion or inhibit absorption in rabbit ileum but do not affect the adenylate cyclase-CAMP system, were shown to increase Ca++ influx across the serosal surface of rabbit ileum and also to increase total ileal calcium content. These neurohumoral substances include carbachol, substance P and neurotensin. It is possible that many neurohumoral substances which cause similar changes in ileal electrolyte transport act by increasing the basolateral membrane permeability to Ca++.",

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AU - Donowitz, Mark

AU - Fogel, Ronald

AU - Battisti, Laurie

AU - Asarkof, Nancy

PY - 1982/11/1

Y1 - 1982/11/1

N2 - Several neurohumoral substances, which cause active electrolyte secretion or inhibit absorption in rabbit ileum but do not affect the adenylate cyclase-CAMP system, were shown to increase Ca++ influx across the serosal surface of rabbit ileum and also to increase total ileal calcium content. These neurohumoral substances include carbachol, substance P and neurotensin. It is possible that many neurohumoral substances which cause similar changes in ileal electrolyte transport act by increasing the basolateral membrane permeability to Ca++.

AB - Several neurohumoral substances, which cause active electrolyte secretion or inhibit absorption in rabbit ileum but do not affect the adenylate cyclase-CAMP system, were shown to increase Ca++ influx across the serosal surface of rabbit ileum and also to increase total ileal calcium content. These neurohumoral substances include carbachol, substance P and neurotensin. It is possible that many neurohumoral substances which cause similar changes in ileal electrolyte transport act by increasing the basolateral membrane permeability to Ca++.

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JF - Life Sciences

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The neurohumoral secretagogues carbachol, substance P and neurotensin increase Ca⁺⁺ influx and calcium content in rabbit ileum

Abstract

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