Abstract
Substantial progress, in part owing to recent refinements in methodology, has been made in unraveling the anatomic correlates of schizophrenia. Subtle pathomorphologic changes, distinct from those of well- known degenerative brain disorders, have been observed. Neurochemical characterization has illuminated the nature of these morphologic abnormalities and has pointed to complex dysregulation of neurotransmitters and G proteins. New biochemical hypotheses such as the glutamate hypothesis have replaced and revitalized more established concepts in the neurochemistry of schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 57-75 |
| Number of pages | 19 |
| Journal | Psychiatric Clinics of North America |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
The neuroanatomy and neurochemistry of schizophrenia. / Weickert, C. S.; Kleinman, Joel.
In: Psychiatric Clinics of North America, Vol. 21, No. 1, 1998, p. 57-75.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The neuroanatomy and neurochemistry of schizophrenia
AU - Weickert, C. S.
AU - Kleinman, Joel
PY - 1998
Y1 - 1998
N2 - Substantial progress, in part owing to recent refinements in methodology, has been made in unraveling the anatomic correlates of schizophrenia. Subtle pathomorphologic changes, distinct from those of well- known degenerative brain disorders, have been observed. Neurochemical characterization has illuminated the nature of these morphologic abnormalities and has pointed to complex dysregulation of neurotransmitters and G proteins. New biochemical hypotheses such as the glutamate hypothesis have replaced and revitalized more established concepts in the neurochemistry of schizophrenia.
AB - Substantial progress, in part owing to recent refinements in methodology, has been made in unraveling the anatomic correlates of schizophrenia. Subtle pathomorphologic changes, distinct from those of well- known degenerative brain disorders, have been observed. Neurochemical characterization has illuminated the nature of these morphologic abnormalities and has pointed to complex dysregulation of neurotransmitters and G proteins. New biochemical hypotheses such as the glutamate hypothesis have replaced and revitalized more established concepts in the neurochemistry of schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=0031944352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031944352&partnerID=8YFLogxK
U2 - 10.1016/S0193-953X(05)70361-0
DO - 10.1016/S0193-953X(05)70361-0
M3 - Review article
C2 - 9551491
AN - SCOPUS:0031944352
VL - 21
SP - 57
EP - 75
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
SN - 0193-953X
IS - 1
ER -