The neuroanatomy and neurochemistry of schizophrenia

C. S. Weickert, J. E. Kleinman

Research output: Contribution to journalArticlepeer-review


Substantial progress, in part owing to recent refinements in methodology, has been made in unraveling the anatomic correlates of schizophrenia. Subtle pathomorphologic changes, distinct from those of well- known degenerative brain disorders, have been observed. Neurochemical characterization has illuminated the nature of these morphologic abnormalities and has pointed to complex dysregulation of neurotransmitters and G proteins. New biochemical hypotheses such as the glutamate hypothesis have replaced and revitalized more established concepts in the neurochemistry of schizophrenia.

Original languageEnglish (US)
Pages (from-to)57-75
Number of pages19
JournalPsychiatric Clinics of North America
Issue number1
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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