The neuroanatomy and neurochemistry of schizophrenia

C. S. Weickert, Joel Kleinman

Research output: Contribution to journalReview article

Abstract

Substantial progress, in part owing to recent refinements in methodology, has been made in unraveling the anatomic correlates of schizophrenia. Subtle pathomorphologic changes, distinct from those of well- known degenerative brain disorders, have been observed. Neurochemical characterization has illuminated the nature of these morphologic abnormalities and has pointed to complex dysregulation of neurotransmitters and G proteins. New biochemical hypotheses such as the glutamate hypothesis have replaced and revitalized more established concepts in the neurochemistry of schizophrenia.

Original languageEnglish (US)
Pages (from-to)57-75
Number of pages19
JournalPsychiatric Clinics of North America
Volume21
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

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Neurochemistry
Neuroanatomy
Schizophrenia
Brain Diseases
GTP-Binding Proteins
Neurotransmitter Agents
Glutamic Acid

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

The neuroanatomy and neurochemistry of schizophrenia. / Weickert, C. S.; Kleinman, Joel.

In: Psychiatric Clinics of North America, Vol. 21, No. 1, 1998, p. 57-75.

Research output: Contribution to journalReview article

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